The Multifaceted Interactions Between Newcastle Disease Virus Proteins and Host Proteins: a Systematic Review

Overview

Journal Virulence

Specialty Microbiology

Date 2024 Jan 9

PMID 38193514

Authors

Xiaolong Lu

Xiaoquan Wang

Xiufan Liu

Xiaowen Liu

Affiliations

Soon will be listed here.

Abstract

Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune evasion during viral transmission, thus imposing enormous challenges to avian health and poultry production. NDV is composed of six structural proteins and two nonstructural proteins that exert pivotal roles in viral infection and antiviral responses by interacting with host proteins. Nowadays, there is a particular focus on the mechanisms of virus-host protein interactions in NDV research, yet a comprehensive overview of such research is still lacking. Herein, we briefly summarize the mechanisms regarding the effects of virus-host protein interaction on viral infection, pathogenesis, and host immune responses. This review can not only enhance the present comprehension of the mechanism underlying NDV and host interplay, but also furnish a point of reference for the advancement of antiviral measures.

Citing Articles

Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus.

Zhou J, Duan Y, Liu M, Liu J, Hu Z, Duan Z Vet Res. 2025; 56(1):8.

PMID: 39800751 PMC: 11726954. DOI: 10.1186/s13567-024-01429-0.

References

Qiu X, Fu Q, Meng C, Yu S, Zhan Y, Dong L . Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection. Acta Virol. 2016; 60(1):71-7. DOI: 10.4149/av_2016_01_71. View

Karsunke J, Heiden S, Murr M, Karger A, Franzke K, Mettenleiter T . W protein expression by Newcastle disease virus. Virus Res. 2019; 263:207-216. DOI: 10.1016/j.virusres.2019.02.003. View

Chen D, Su A, Fu Y, Wang X, Lv X, Xu W . Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral Res. 2015; 123:27-38. DOI: 10.1016/j.antiviral.2015.09.003. View

Zhou L, Han Y, Yuan C, Duan Z . Screening and bioinformatics analysis of cellular proteins interacting with chicken bromodomain-containing protein 2 in DF-1 cells. Br Poult Sci. 2021; 62(6):810-819. DOI: 10.1080/00071668.2021.1943311. View

Molouki A, Peeters B . Rescue of recombinant Newcastle disease virus: a short history of how it all started. Arch Virol. 2017; 162(7):1845-1854. DOI: 10.1007/s00705-017-3308-2. View

Duan Z, Song Q, Wang Y, He L, Chen J, Zhu Y . Characterization of signal sequences determining the nuclear export of Newcastle disease virus matrix protein. Arch Virol. 2013; 158(12):2589-95. DOI: 10.1007/s00705-013-1769-5. View

Tang Y, Zhan W, Cao T, Tang T, Gao Y, Qiu Z . CacyBP/SIP inhibits Doxourbicin-induced apoptosis of glioma cells due to activation of ERK1/2. IUBMB Life. 2016; 68(3):211-9. DOI: 10.1002/iub.1477. View

Juilland M, Thome M . Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies. Curr Opin Hematol. 2016; 23(4):402-9. PMC: 4900422. DOI: 10.1097/MOH.0000000000000257. View

Cibulka J, Fraiberk M, Forstova J . Nuclear actin and lamins in viral infections. Viruses. 2012; 4(3):325-47. PMC: 3347030. DOI: 10.3390/v4030325. View

10.

Lu X, Liu K, Chen Y, Gao R, Hu Z, Hu J . Cellular vimentin regulates the infectivity of Newcastle disease virus through targeting of the HN protein. Vet Res. 2023; 54(1):92. PMC: 10580610. DOI: 10.1186/s13567-023-01230-5. View

11.

Sun J, Han Z, Qi T, Zhao R, Liu S . Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein. J Biol Chem. 2017; 292(49):20141-20161. PMC: 5724002. DOI: 10.1074/jbc.M116.772897. View

12.

Motz C, Schuhmann K, Kirchhofer A, Moldt M, Witte G, Conzelmann K . Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Science. 2013; 339(6120):690-3. DOI: 10.1126/science.1230949. View

13.

Ren S, Rehman Z, Gao B, Yang Z, Zhou J, Meng C . ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells. PLoS Pathog. 2020; 16(6):e1008514. PMC: 7263568. DOI: 10.1371/journal.ppat.1008514. View

14.

Wang C, Wang T, Hu R, Duan L, Hou Q, Han Y . 9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β. J Virol. 2023; 97(3):e0198422. PMC: 10062145. DOI: 10.1128/jvi.01984-22. View

15.

Battisti A, Meng G, Winkler D, McGinnes L, Plevka P, Steven A . Structure and assembly of a paramyxovirus matrix protein. Proc Natl Acad Sci U S A. 2012; 109(35):13996-4000. PMC: 3435216. DOI: 10.1073/pnas.1210275109. View

16.

Fagerberg L, Hallstrom B, Oksvold P, Kampf C, Djureinovic D, Odeberg J . Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 2013; 13(2):397-406. PMC: 3916642. DOI: 10.1074/mcp.M113.035600. View

17.

Chen S, Zhang Q, Xu D, Li Y, Fan Y, Li W . Antitumor effect of the Newcastle disease viral hemagglutinin-neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells. Anticancer Drugs. 2018; 29(3):197-207. DOI: 10.1097/CAD.0000000000000575. View

18.

Wang C, Chu Z, Liu W, Pang Y, Gao X, Tang Q . Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1. Vet Res. 2018; 49(1):102. PMC: 6389150. DOI: 10.1186/s13567-018-0599-6. View

19.

Pantua H, McGinnes L, Peeples M, Morrison T . Requirements for the assembly and release of Newcastle disease virus-like particles. J Virol. 2006; 80(22):11062-73. PMC: 1642154. DOI: 10.1128/JVI.00726-06. View

20.

Kim Y, Han M, Oh S . The molecular mechanism for nuclear transport and its application. Anat Cell Biol. 2017; 50(2):77-85. PMC: 5509903. DOI: 10.5115/acb.2017.50.2.77. View