Antacids and Peptic Ulcer--a Reappraisal

Overview

Journal Gut

Specialty Gastroenterology

Date 1979 Jun 1

PMID 38192

Citations 6

Authors

T Morris

J Rhodes

Affiliations

Soon will be listed here.

Abstract

Antacids can reduce gastroduodenal acidity for long periods if taken in substantial quantities after food. Their healing effect on gastric ulcer is minimal, if present at all, and easily overwhelmed by the benefit obtained from admission to hospital. Intensive antacid therapy appears effective in healing duodenal ulcer and preventing haemorrhage from stress ulcer, and is comparable in these respects with cimetidine but with a higher incidence of side-effects. Clinical impression strongly suggests that antacids relieve pain in peptic ulcer but objective confirmation is lacking.

Citing Articles

A comparative overview of the adverse effects of antiulcer drugs.

Piper D Drug Saf. 1995; 12(2):120-38.

PMID: 7766337 DOI: 10.2165/00002018-199512020-00005.

Problems in the medical treatment of peptic ulcers.

Wormsley K J R Coll Physicians Lond. 1980; 14(3):169-72.

PMID: 7205728 PMC: 5373237.

Is there a place in the United Kingdom for intensive antacid treatment for chronic peptic ulceration?.

Faizallah R, de Haan H, Krasner N, Walker R, Morris A, Calam M Br Med J (Clin Res Ed). 1984; 289(6449):869-71.

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Current therapy in peptic ulcer.

Marks I Drugs. 1980; 20(4):283-99.

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Antacids and duodenal ulcer.

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