Acute and Subchronic Oral Toxicity Study of Oil in Wistar Rats

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jan 8

PMID 38187340

Authors

Ying Xia

Jie Zhu

Min Qu

Wenxiang Yang

Shaohua Fu

Liqin Yu

Bolin Fan

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of these studies was to ascertain if oil is harmful in both the acute and subchronic states.

Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral oil was greater than 27.6 g/kg bw. Rats were gavaged with oil at dosages of 0.00, 0.92, 1.84, and 3.68 g/kg bw per day for 90 days. In addition, satellite groups were established in the control and high-dose groups for a 28-day recovery period. The following factors were assessed: mortality, clinical anomalies, body weight, food intake, hematological, serum biochemistry, urine, gross necropsy, and histology.

Results: There were no observable toxicity-related changes in any of the three dosage groups. There is no toxicological relevance to the change in the high-dose hematological indicator PLT at the conclusion of the recovery period because it was within the usual range for this strain in our laboratory. The test material did not result in any pathological alterations, according to a pathological examination.

Conclusion: Since the results of the current study, the no-observed-adverse-effect-level (NOAEL) for oil in rats has been determined to be greater than 3.68 g/kg bw.

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