MiRNA Signatures in Nasopharyngeal Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2024 Jan 8

PMID 38187072

Authors

Yan Chen

Ting Lin

Le Tang

Lan He

Yingchun He

Affiliations

Soon will be listed here.

Abstract

Nasopharyngeal carcinoma (NPC) is a prevalent cancerous tumor that affects the head and neck region. Recent studies have provided compelling evidence indicating the significant involvement of microRNAs (miRNAs) in the development and progression of NPC. This review aims to present a comprehensive summary of the current knowledge regarding miRNA signatures in NPC, encompassing their expression patterns, molecular mechanisms, and potential therapeutic implications. Initially, the article outlines the aberrant expression of miRNAs in NPC and elucidates their roles in tumor initiation, invasion, and metastasis. Subsequently, the underlying molecular mechanisms of miRNA-mediated regulation of NPC-associated signaling pathways are discussed. Additionally, the review highlights the potential clinical applications of miRNAs as diagnostic and prognostic biomarkers, as well as their therapeutic potential in NPC treatment. In conclusion, this review underscores the critical involvement of miRNAs in NPC pathogenesis and underscores their promise as novel therapeutic targets for combating this devastating disease.

Citing Articles

Intravoxel incoherent motion diffusion-weighted imaging in nasopharyngeal carcinoma: comparison of the turbo spin-echo and echo-planar imaging techniques.

Liu Y, Hu L, Qian L, Chen M, Xu S, Sun P Quant Imaging Med Surg. 2024; 14(12):9101-9111.

PMID: 39698659 PMC: 11652045. DOI: 10.21037/qims-24-1021.

Global trends in research of nasopharyngeal carcinoma: a bibliometric and visualization analysis.

An G, Liu J, Lin T, He L, He Y Front Oncol. 2024; 14:1392245.

PMID: 39015496 PMC: 11249725. DOI: 10.3389/fonc.2024.1392245.

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