Mechanism Study of Oleanolic Acid Derivative, K73-03, Inducing Cell Apoptosis in Hepatocellular Carcinoma

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2024 Jan 7

PMID 38185661

Authors

Jiaqi Wang

Chuchu Ma

Zhongyuan Tang

Zhengwu Sun

Eskandar Qaed

Xinming Chi

Jun Wang

Yazeed Jamalat

Zhaohong Geng

Zeyao Tang

Qiying Yao

Affiliations

Soon will be listed here.

Abstract

Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits its bioavailability and application. In this study, a new OA derivative, K73-03, was used to determine its effect on liver cancer cells and detailed molecular mechanisms. Here, we show that K73-03 may lead to the disorder of mitochondria in HepG2 cells, leading to excessive ROS production and apoptosis in cells. Meanwhile, K73-03 could induce cell apoptosis by inhibiting JAK2/STAT3 pathway and NF-κB/P65 pathway. Collectively, this study may provide a preliminary basis for further cancer treatment of hepatocellular carcinoma.

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