Sesamol As a Potent Anticancer Compound: from Chemistry to Cellular Interactions

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2024 Jan 5

PMID 38180556

Authors

Ajay Kumar

Payal Bajaj

Brahmjot Singh

Kapil Paul

Pooja Sharma

Sukanya Mehra

Robin

Pardeep Kaur

Shivam Jasrotia

Parveen Kumar

Rajat

Vipourpreet Singh

Hardeep Singh Tuli

Affiliations

Soon will be listed here.

Abstract

Sesamol (SM), a well-known component isolated from sesame seeds (Sesamum indicum), used in traditional medicines in treating numerous ailments. However, numerous molecular investigations revealed the various mechanisms behind its activity, emphasizing its antiproliferative, anti-inflammatory, and apoptosis-inducing properties, preventing cancer cell spread to distant organs. In several cells derived from various malignant tissues, SM-regulated signal transduction pathways and cellular targets have been identified. This review paper comprehensively describes the anticancer properties of SM and SM-viable anticancer drugs. Additionally, the interactions of this natural substance with standard anticancer drugs are examined, and the benefits of using nanotechnology in SM applications are explored. This makes SM a prime example of how ethnopharmacological knowledge can be applied to the development of contemporary drugs.

Citing Articles

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Mostashari P, Khaneghah A Foods. 2024; 13(8).

PMID: 38672826 PMC: 11049391. DOI: 10.3390/foods13081153.

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