Combined Extended Reality and Reinforcement Learning to Promote Healthcare and Reduce Social Anxiety in Fragile X Syndrome: a New Assessment Tool and a Rehabilitative Strategy

Overview

Journal Front Psychol

Date 2024 Jan 5

PMID 38179497

Authors

Fabrizio Stasolla

Anna Passaro

Mariacarla Di Gioia

Enza Curcio

Antonio Zullo

Affiliations

Soon will be listed here.

Citing Articles

Integrating reinforcement learning and serious games to support people with rare genetic diseases and neurodevelopmental disorders: outcomes on parents and caregivers.

Stasolla F, Akbar K, Passaro A, Dragone M, Di Gioia M, Zullo A Front Psychol. 2024; 15:1372769.

PMID: 38646123 PMC: 11026657. DOI: 10.3389/fpsyg.2024.1372769.

References

Stasolla F, Matamala-Gomez M, Bernini S, Caffo A, Bottiroli S . Virtual Reality as a Technological-Aided Solution to Support Communication in Persons With Neurodegenerative Diseases and Acquired Brain Injury During COVID-19 Pandemic. Front Public Health. 2021; 8:635426. PMC: 7921156. DOI: 10.3389/fpubh.2020.635426. View

Bernini S, Gerbasi A, Panzarasa S, Quaglini S, Ramusino M, Costa A . Outcomes of a computer-based cognitive training (CoRe) in early phases of cognitive decline: a data-driven cluster analysis. Sci Rep. 2023; 13(1):2175. PMC: 9905613. DOI: 10.1038/s41598-022-26924-2. View

Cregenzan-Royo O, Brun-Gasca C, Fornieles-Deu A . Behavior Problems and Social Competence in Fragile X Syndrome: A Systematic Review. Genes (Basel). 2022; 13(2). PMC: 8871871. DOI: 10.3390/genes13020280. View

Pousada Garcia T, Garabal-Barbeira J, Porto Trillo P, Vilar Figueira O, Novo Diaz C, Pereira Loureiro J . A Framework for a New Approach to Empower Users Through Low-Cost and Do-It-Yourself Assistive Technology. Int J Environ Res Public Health. 2021; 18(6). PMC: 8001483. DOI: 10.3390/ijerph18063039. View

Caffo A, Lopez A, Spano G, Saracino G, Stasolla F, Ciriello G . The role of pre-morbid intelligence and cognitive reserve in predicting cognitive efficiency in a sample of Italian elderly. Aging Clin Exp Res. 2016; 28(6):1203-1210. DOI: 10.1007/s40520-016-0580-z. View

Chen G, Geschwind D . Challenges and opportunities for precision medicine in neurodevelopmental disorders. Adv Drug Deliv Rev. 2022; 191:114564. PMC: 10409256. DOI: 10.1016/j.addr.2022.114564. View

Symons F, Clark R, Hatton D, Skinner M, Bailey Jr D . Self-injurious behavior in young boys with fragile X syndrome. Am J Med Genet A. 2003; 118A(2):115-21. DOI: 10.1002/ajmg.a.10078. View

Lancioni G, OReilly M, Singh N, Stasolla F, MANFREDI F, Oliva D . Adapting a grid into a microswitch to suit simple hand movements of a child with profound multiple disabilities. Percept Mot Skills. 2004; 99(2):724-8. DOI: 10.2466/pms.99.2.724-728. View

Prior D, Win S, Hassiotis A, Hall I, Martiello M, Ali A . Behavioural and cognitive-behavioural interventions for outwardly directed aggressive behaviour in people with intellectual disabilities. Cochrane Database Syst Rev. 2023; 2:CD003406. PMC: 9901280. DOI: 10.1002/14651858.CD003406.pub5. View

10.

Aishworiya R, Protic D, Hagerman R . Autism spectrum disorder in the fragile X premutation state: possible mechanisms and implications. J Neurol. 2022; 269(9):4676-4683. DOI: 10.1007/s00415-022-11209-5. View

11.

Edwards G, Jones C, Pearson E, Royston R, Oliver C, Tarver J . Prevalence of anxiety symptomatology and diagnosis in syndromic intellectual disability: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2022; 138:104719. DOI: 10.1016/j.neubiorev.2022.104719. View

12.

Jones R, Hussain F, Agha S, Weavers B, Lucassen M, Merry S . Digital technologies to support adolescents with depression and anxiety: review. BJPsych Adv. 2023; 29(4):239-253. PMC: 10374830. DOI: 10.1192/bja.2022.3. View

13.

Crawford H . Social Anxiety in Neurodevelopmental Disorders: The Case of Fragile X Syndrome. Am J Intellect Dev Disabil. 2023; 128(4):302-318. DOI: 10.1352/1944-7558-128.4.302. View

14.

Gabis L, Shaham M, Attia O, Kowal T, David S, Banet-Levi Y . An escalating continuum of learning and attention difficulties from premutation to full mutation in female carriers of expansion. Front Neurol. 2023; 14:1135630. PMC: 10185778. DOI: 10.3389/fneur.2023.1135630. View

15.

Lopez-Vargas P, Tong A, Crowe S, Alexander S, Caldwell P, Campbell D . Research priorities for childhood chronic conditions: a workshop report. Arch Dis Child. 2018; 104(3):237-245. DOI: 10.1136/archdischild-2018-315628. View

16.

Marlborough M, Welham A, Jones C, Reckless S, Moss J . Autism spectrum disorder in females with fragile X syndrome: a systematic review and meta-analysis of prevalence. J Neurodev Disord. 2021; 13(1):28. PMC: 8299695. DOI: 10.1186/s11689-021-09362-5. View

17.

Ren X, Wu Q, Cui N, Zhao J, Bi H . Effectiveness of digital game-based trainings in children with neurodevelopmental disorders: A meta-analysis. Res Dev Disabil. 2023; 133:104418. DOI: 10.1016/j.ridd.2022.104418. View

18.

Coronato A, Naeem M, De Pietro G, Paragliola G . Reinforcement learning for intelligent healthcare applications: A survey. Artif Intell Med. 2021; 109:101964. DOI: 10.1016/j.artmed.2020.101964. View

19.

Ellis K, Moss J, Stefanidou C, Oliver C, Apperly I . The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein-Taybi syndromes. Orphanet J Rare Dis. 2021; 16(1):488. PMC: 8607585. DOI: 10.1186/s13023-021-02117-4. View

20.

Kim H, Koh H . Impaired Reality Testing in Mice Lacking Phospholipase Cβ1: Observed by Persistent Representation-Mediated Taste Aversion. PLoS One. 2016; 11(1):e0146376. PMC: 4701129. DOI: 10.1371/journal.pone.0146376. View