Understanding Islet Autoantibodies in Prediction of Type 1 Diabetes

Overview

Journal J Endocr Soc

Specialty Endocrinology

Date 2024 Jan 3

PMID 38169963

Authors

Xiaofan Jia

Liping Yu

Affiliations

Soon will be listed here.

Abstract

As screening studies and preventive interventions for type 1 diabetes (T1D) advance rapidly, the utility of islet autoantibodies (IAbs) in T1D prediction comes with challenges for early and accurate disease progression prediction. Refining features of IAbs can provide more accurate risk assessment. The advances in islet autoantibodies assay techniques help to screen out islet autoantibodies with high efficiency and high disease specificity. Exploring new islet autoantibodies to neoepitopes/neoantigens remains a hot research field for improving prediction and disease pathogenesis. We will review the recent research progresses of islet autoantibodies to better understand the utility of islet autoantibodies in prediction of T1D.

Citing Articles

Autoimmune Type 1 Diabetes: An Early Approach Appraisal for Spain by the AGORA Diabetes Collaborative Group.

Gomez-Peralta F, Pines-Corrales P, Santos E, Cuesta M, Gonzalez-Albarran O, Azriel S J Clin Med. 2025; 14(2).

PMID: 39860426 PMC: 11766439. DOI: 10.3390/jcm14020418.

Development and validation of a novel method for evaluation of multiple islet autoantibodies in dried blood spot using dissociation-enhanced lanthanide fluorescent immunoassays technology, specific and suitable for paediatric screening programmes.

Dufrusine B, Natale L, Sallese M, Mozzillo E, Candia F, Cuccurullo I Diabetes Obes Metab. 2024; 27(1):414-418.

PMID: 39429062 PMC: 11618293. DOI: 10.1111/dom.16002.

Exploring senescence as a modifier of β cell extracellular vesicles in type 1 diabetes.

Motlagh R, Pipella J, Thompson P Front Endocrinol (Lausanne). 2024; 15:1422279.

PMID: 39239092 PMC: 11374605. DOI: 10.3389/fendo.2024.1422279.

Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies.

Yasmeen F, Pirzada R, Ahmad B, Choi B, Choi S Int J Mol Sci. 2024; 25(14).

PMID: 39062908 PMC: 11277571. DOI: 10.3390/ijms25147666.

Estimation of Individual Positive Anti-Islet Autoantibodies from 3 Screen ICA Titer.

Kawasaki E, Jinnouchi H, Maeda Y, Okada A, Kawai K Int J Mol Sci. 2024; 25(14).

PMID: 39062856 PMC: 11277171. DOI: 10.3390/ijms25147618.

References

Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M . Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care. 2021; 45(1):160-168. PMC: 8753764. DOI: 10.2337/dc21-0878. View

Schlosser M, Koczwara K, Kenk H, Strebelow M, Rjasanowski I, Wassmuth R . In insulin-autoantibody-positive children from the general population, antibody affinity identifies those at high and low risk. Diabetologia. 2005; 48(9):1830-2. DOI: 10.1007/s00125-005-1864-6. View

Ziegler A, Kick K, Bonifacio E, Haupt F, Hippich M, Dunstheimer D . Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany. JAMA. 2020; 323(4):339-351. PMC: 6990943. DOI: 10.1001/jama.2019.21565. View

Acevedo-Calado M, James E, Morran M, Pietropaolo S, OuYang Q, Arribas-Layton D . Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017; 40(4):561-568. PMC: 5360285. DOI: 10.2337/dc16-1527. View

Steck A, Johnson K, Barriga K, Miao D, Yu L, Hutton J . Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care. 2011; 34(6):1397-9. PMC: 3114355. DOI: 10.2337/dc10-2088. View

Wenzlau J, Liu Y, Yu L, Moua O, Fowler K, Rangasamy S . A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes. 2008; 57(10):2693-7. PMC: 2551679. DOI: 10.2337/db08-0522. View

Herold K, Bundy B, Long S, Bluestone J, DiMeglio L, Dufort M . An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019; 381(7):603-613. PMC: 6776880. DOI: 10.1056/NEJMoa1902226. View

So M, ORourke C, Bahnson H, Greenbaum C, Speake C . Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals. Diabetes Care. 2020; 43(4):913-917. PMC: 7085807. DOI: 10.2337/dc19-1731. View

Bender C, Rajendran S, von Herrath M . New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes. Front Endocrinol (Lausanne). 2021; 11:606434. PMC: 7813992. DOI: 10.3389/fendo.2020.606434. View

10.

Steck A, Rewers M . Genetics of type 1 diabetes. Clin Chem. 2011; 57(2):176-85. PMC: 4874193. DOI: 10.1373/clinchem.2010.148221. View

11.

Bingley P, Boulware D, Krischer J . The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes. Diabetologia. 2015; 59(3):542-9. PMC: 4742489. DOI: 10.1007/s00125-015-3830-2. View

12.

Ziegler A, Rewers M, Simell O, Simell T, Lempainen J, Steck A . Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA. 2013; 309(23):2473-9. PMC: 4878912. DOI: 10.1001/jama.2013.6285. View

13.

Eisenbarth G . Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986; 314(21):1360-8. DOI: 10.1056/NEJM198605223142106. View

14.

Steck A, Vehik K, Bonifacio E, Lernmark A, Ziegler A, Hagopian W . Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015; 38(5):808-13. PMC: 4407751. DOI: 10.2337/dc14-2426. View

15.

Jia X, He L, Miao D, Waugh K, Geno Rasmussen C, Dong F . High-affinity ZnT8 Autoantibodies by Electrochemiluminescence Assay Improve Risk Prediction for Type 1 Diabetes. J Clin Endocrinol Metab. 2021; 106(12):3455-3463. PMC: 8864749. DOI: 10.1210/clinem/dgab575. View

16.

Ng K, Anand V, Stavropoulos H, Veijola R, Toppari J, Maziarz M . Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children. Diabetologia. 2022; 66(1):93-104. PMC: 9729160. DOI: 10.1007/s00125-022-05799-y. View

17.

Mayr A, Schlosser M, Grober N, Kenk H, Ziegler A, Bonifacio E . GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes. Diabetes. 2007; 56(6):1527-33. DOI: 10.2337/db06-1715. View

18.

Arribas-Layton D, Guyer P, Delong T, Dang M, Chow I, Speake C . Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01. Diabetes. 2020; 69(7):1492-1502. PMC: 7306133. DOI: 10.2337/db19-0620. View

19.

Rabin D, Pleasic S, Shapiro J, Oles J, Hicks J, Goldstein D . Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol. 1994; 152(6):3183-8. View

20.

Rewers A, Dong F, Slover R, Klingensmith G, Rewers M . Incidence of diabetic ketoacidosis at diagnosis of type 1 diabetes in Colorado youth, 1998-2012. JAMA. 2015; 313(15):1570-2. DOI: 10.1001/jama.2015.1414. View