Seventy-five Years of Service: an Overview of the College of American Pathologists' Proficiency Testing Program in Histocompatibility and Identity Testing

Overview

Journal Front Genet

Date 2024 Jan 3

PMID 38169613

Authors

H Cliff Sullivan

Manish J Gandhi

Sujata Gaitonde

Ramya Narasimhan

Ketevan Gendzekhadze

Soumya Pandey

Rhonda K Roby

George C Maha

Harmeet Kaur

Jennifer J Schiller

Julie McDowell

Maria Smith

Chang Liu

Gerald P Morris

Affiliations

Soon will be listed here.

Abstract

The Histocompatibility and Identity Testing Committee offers an overview of the College of American Pathologists' (CAP) Proficiency Testing (PT) program, commemorating its significant 75th anniversary in 2024. The CAP PT program has undergone significant growth and evolution over the years, ultimately achieving Centers for Medicare and Medicaid Services approval. In 1979, CAP's partnership with the American Association for Clinical Histocompatibility Testing marked a pivotal moment, leading to the creation of the first proficiency testing survey in 1980. This laid the foundation for various PT programs managed by the CAP Histocompatibility and Identity Testing Committee, including HLA antibody testing, HLA molecular typing, engraftment monitoring, parentage/relationship testing, HLA disease associations and drug risk, and HLA-B27 typing. Each program's distinctive considerations, grading methodologies, and future prospects are detailed here, highlighting the continual evolution of histocompatibility and identity testing PT to support emerging technologies and evolving laboratory practices in the field.

References

Mayor N, Wang T, Lee S, Kuxhausen M, Vierra-Green C, Barker D . Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation. J Clin Oncol. 2021; 39(21):2397-2409. PMC: 8280068. DOI: 10.1200/JCO.20.03643. View

Wiebe C, Gibson I, Blydt-Hansen T, Karpinski M, Ho J, Storsley L . Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant. 2012; 12(5):1157-67. DOI: 10.1111/j.1600-6143.2012.04013.x. View

Sciurti M, Fornaroli F, Gaiani F, Bonaguri C, Leandro G, Di Mario F . Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?. Acta Biomed. 2018; 89(9-S):17-21. PMC: 6502200. DOI: 10.23750/abm.v89i9-S.7953. View

Tait B . Detection of HLA Antibodies in Organ Transplant Recipients - Triumphs and Challenges of the Solid Phase Bead Assay. Front Immunol. 2016; 7:570. PMC: 5146910. DOI: 10.3389/fimmu.2016.00570. View

Holdsworth R, Hurley C, Marsh S, Lau M, Noreen H, Kempenich J . The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens. Tissue Antigens. 2009; 73(2):95-170. DOI: 10.1111/j.1399-0039.2008.01183.x. View

Levinson G, Gutman G . Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol Biol Evol. 1987; 4(3):203-21. DOI: 10.1093/oxfordjournals.molbev.a040442. View

Clark J, Scott S, Jack A, Lee H, Mason J, Carter G . Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): technical recommendations for the use of short tandem repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment.... Br J Haematol. 2014; 168(1):26-37. DOI: 10.1111/bjh.13073. View

Mayor N, Hayhurst J, Turner T, Szydlo R, Shaw B, Bultitude W . Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study. Biol Blood Marrow Transplant. 2019; 25(3):443-450. DOI: 10.1016/j.bbmt.2018.12.768. View

Dunn P . Human leucocyte antigen typing: techniques and technology, a critical appraisal. Int J Immunogenet. 2011; 38(6):463-73. DOI: 10.1111/j.1744-313X.2011.01040.x. View

10.

Hurley C, Kempenich J, Wadsworth K, Sauter J, Hofmann J, Schefzyk D . Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0. HLA. 2020; 95(6):516-531. PMC: 7317522. DOI: 10.1111/tan.13811. View

11.

Ko T, Tsai C, Chen S, Chen K, Yu K, Chu C . Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study. BMJ. 2015; 351:h4848. PMC: 4579807. DOI: 10.1136/bmj.h4848. View

12.

Choung R, Mills J, Snyder M, Murray J, Gandhi M . Celiac disease risk stratification based on HLA-DQ heterodimer (HLA-DQA1 ~ DQB1) typing in a large cohort of adults with suspected celiac disease. Hum Immunol. 2020; 81(2-3):59-64. DOI: 10.1016/j.humimm.2020.01.006. View

13.

Levering W, Wind H, Sintnicolaas K, Hooijkaas H, Gratama J . Flow cytometric HLA-B27 screening: cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens. Cytometry B Clin Cytom. 2003; 54(1):28-38. DOI: 10.1002/cyto.b.10022. View

14.

Zhang F, Liu H, Irwanto A, Fu X, Li Y, Yu G . HLA-B*13:01 and the dapsone hypersensitivity syndrome. N Engl J Med. 2013; 369(17):1620-8. DOI: 10.1056/NEJMoa1213096. View

15.

Pena J, Fung M, Gandhi M . A Review of Laboratory Practices Using the HLA-B27 Survey by the College of American Pathologists: How Important Is Allele-Level Typing?. Arch Pathol Lab Med. 2023; 148(2):149-154. DOI: 10.5858/arpa.2022-0322-CP. View

16.

McCormack M, Alfirevic A, Bourgeois S, Farrell J, Kasperaviciute D, Carrington M . HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011; 364(12):1134-43. PMC: 3113609. DOI: 10.1056/NEJMoa1013297. View

17.

Gladstone D, Bettinotti M . HLA donor-specific antibodies in allogeneic hematopoietic stem cell transplantation: challenges and opportunities. Hematology Am Soc Hematol Educ Program. 2017; 2017(1):645-650. PMC: 6142580. DOI: 10.1182/asheducation-2017.1.645. View

18.

De Santis D, Dinauer D, Duke J, Erlich H, Holcomb C, Lind C . 16(th) IHIW : review of HLA typing by NGS. Int J Immunogenet. 2013; 40(1):72-6. PMC: 4793271. DOI: 10.1111/iji.12024. View

19.

Hancock J, Goulden N, Oakhill A, Steward C . Quantitative analysis of chimerism after allogeneic bone marrow transplantation using immunomagnetic selection and fluorescent microsatellite PCR. Leukemia. 2003; 17(1):247-51. DOI: 10.1038/sj.leu.2402759. View

20.

Jackson A . The Virtual Crossmatch: An Essential Tool for Transplanting Sensitized Patients. Clin Transpl. 2015; :131-6. View