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Non-coding RNAs Regulating Endothelial Progenitor Cells for Venous Thrombosis: Promising Therapy and Innovation

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Publisher Biomed Central
Date 2024 Jan 3
PMID 38169418
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Abstract

Venous thromboembolism, which includes deep venous thrombosis (DVT) and pulmonary embolism, is the third most common vascular disease in the world and seriously threatens the lives of patients. Currently, the effect of conventional treatments on DVT is limited. Endothelial progenitor cells (EPCs) play an important role in the resolution and recanalization of DVT, but an unfavorable microenvironment reduces EPC function. Non-coding RNAs, especially long non-coding RNAs and microRNAs, play a crucial role in improving the biological function of EPCs. Non-coding RNAs have become clinical biomarkers of diseases and are expected to serve as new targets for disease intervention. A theoretical and experimental basis for the development of new methods for preventing and treating DVT in the clinic will be provided by studies on the role and molecular mechanism of non-coding RNAs regulating EPC function in the occurrence and development of DVT. To summarize, the characteristics of venous thrombosis, the regulatory role of EPCs in venous thrombosis, and the effect of non-coding RNAs regulating EPCs on venous thrombosis are reviewed. This summary serves as a useful reference and theoretical basis for research into the diagnosis, prevention, treatment, and prognosis of venous thrombosis.

References
1.
Prandoni P, Lensing A, Cogo A, Cuppini S, Villalta S, Carta M . The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996; 125(1):1-7. DOI: 10.7326/0003-4819-125-1-199607010-00001. View

2.
Hembrom A, Srivastava S, Garg I, Kumar B . MicroRNAs in venous thrombo-embolism. Clin Chim Acta. 2020; 504:66-72. DOI: 10.1016/j.cca.2020.01.034. View

3.
Engeseth M, Enden T, Sandset P, Wik H . Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study. Thromb J. 2021; 19(1):3. PMC: 7796540. DOI: 10.1186/s12959-020-00253-8. View

4.
Nourse J, Braun J, Lackner K, Huttelmaier S, Danckwardt S . Large-scale identification of functional microRNA targeting reveals cooperative regulation of the hemostatic system. J Thromb Haemost. 2018; 16(11):2233-2245. DOI: 10.1111/jth.14290. View

5.
Alessio A, Beltrame M, Nascimento M, Vicente C, de Godoy J, Silva J . Circulating progenitor and mature endothelial cells in deep vein thrombosis. Int J Med Sci. 2013; 10(12):1746-54. PMC: 3805926. DOI: 10.7150/ijms.6887. View