Effects of Physical Exercise on Executive Functions of Individuals with Schizophrenia Spectrum Disorders: Protocol for a Systematic Review and Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Jan 2

PMID 38165903

Authors

Nuria Perez-Romero

Christian Campos-Jara

Caterina Pesce

Sergio Araya Sierralta

Enrique Cerda-Vega

Rodrigo Ramirez-Campillo

Rodrigo Campos-Jara

Cristian Martinez-Salazar

Cristian Arellano-Roco

Falonn Contreras-Osorio

Affiliations

Soon will be listed here.

Abstract

Introduction: Executive functions are commonly impaired in individuals with schizophrenia spectrum disorders. Physical exercise has the potential for improving executive functions and can be easily implemented as a therapeutic method. However, there are only few systematic reviews of exercise effects in schizophrenia including cognitive outcomes, and no meta-analytical syntheses of effects on "cool" and "hot" executive functions. The purpose of this systematic review and meta-analysis will be to determine the effects of physical exercise on "cool" and "hot" executive functions of adults with schizophrenia spectrum disorders.

Methods And Analysis: This protocol was guided by PRISMA-P guidelines. Studies will be searched using combinations of keywords and medical terms in the Web of Science, PubMed, Scopus, and EBSCO databases. Inclusion criteria will be determined as per PICOS approach. The risk of bias will be assessed using the Cochrane RoB2 tool. The certainty of evidence (per outcome) will be assessed using the GRADE method. The meta-analyses will be performed using the DerSimonian and Laird random effects model. Effect sizes (Hedges' g) with 95% confidence intervals will be calculated for each main outcome.

Conclusions: The results of this review may be useful for mental health professionals to design treatment plans for adults with schizophrenia spectrum disorders, offering potential benefits related to the quality of life and cognitive abilities of this population.

Prospero Registration Number: CRD42023392295.

Citing Articles

Effects of Resistance Training on Executive Functions of Cognitively Healthy Older Adults: A Systematic Review and Meta-Analysis Protocol.

Jerez-Salas F, Campos-Jara C, Araya Sierralta S, Jerez-Mayorga D, Ramirez-Campillo R, Contreras-Diaz G Healthcare (Basel). 2025; 13(2).

PMID: 39857192 PMC: 11764570. DOI: 10.3390/healthcare13020165.

Effects of Physical Exercise on Emotional Intelligence from Birth to Adolescence: A Systematic Review Protocol.

Contreras-Osorio F, Cerda-Vega E, Campos-Jara C, Ramirez-Campillo R, Perez-Romero N Healthcare (Basel). 2024; 12(23).

PMID: 39685058 PMC: 11640837. DOI: 10.3390/healthcare12232437.

References

Leyland L, Spencer B, Beale N, Jones T, van Reekum C . The effect of cycling on cognitive function and well-being in older adults. PLoS One. 2019; 14(2):e0211779. PMC: 6388745. DOI: 10.1371/journal.pone.0211779. View

Walker E, McGee R, Druss B . Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry. 2015; 72(4):334-41. PMC: 4461039. DOI: 10.1001/jamapsychiatry.2014.2502. View

van der Stouwe E, van Busschbach J, de Vries B, Cahn W, Aleman A, Pijnenborg G . Neural correlates of exercise training in individuals with schizophrenia and in healthy individuals: A systematic review. Neuroimage Clin. 2018; 19:287-301. PMC: 6050351. DOI: 10.1016/j.nicl.2018.04.018. View

Lepage M, Bodnar M, Bowie C . Neurocognition: clinical and functional outcomes in schizophrenia. Can J Psychiatry. 2014; 59(1):5-12. PMC: 4079224. DOI: 10.1177/070674371405900103. View

Silveira-Rodrigues J, Gardenia de Holanda Marinho Nogueira N, Faria L, Pereira D, Soares D . Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2023; 131(6):345-353. DOI: 10.1055/a-2069-4050. View

Liu N, Daumit G, Dua T, Aquila R, Charlson F, Cuijpers P . Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry. 2017; 16(1):30-40. PMC: 5269481. DOI: 10.1002/wps.20384. View

Serra L, Petrosini L, Mandolesi L, Bonarota S, Balsamo F, Bozzali M . Walking, Running, Swimming: An Analysis of the Effects of Land and Water Aerobic Exercises on Cognitive Functions and Neural Substrates. Int J Environ Res Public Health. 2022; 19(23). PMC: 9740550. DOI: 10.3390/ijerph192316310. View

Kern R, Nuechterlein K, Green M, Baade L, Fenton W, Gold J . The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization. Am J Psychiatry. 2008; 165(2):214-20. DOI: 10.1176/appi.ajp.2007.07010043. View

Balshem H, Helfand M, Schunemann H, Oxman A, Kunz R, Brozek J . GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011; 64(4):401-6. DOI: 10.1016/j.jclinepi.2010.07.015. View

10.

Chen F, Etnier J, Chan K, Chiu P, Hung T, Chang Y . Effects of Exercise Training Interventions on Executive Function in Older Adults: A Systematic Review and Meta-Analysis. Sports Med. 2020; 50(8):1451-1467. PMC: 7376513. DOI: 10.1007/s40279-020-01292-x. View

11.

Mikkelsen K, Stojanovska L, Polenakovic M, Bosevski M, Apostolopoulos V . Exercise and mental health. Maturitas. 2017; 106:48-56. DOI: 10.1016/j.maturitas.2017.09.003. View

12.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

13.

Favril L, Yu R, Uyar A, Sharpe M, Fazel S . Risk factors for suicide in adults: systematic review and meta-analysis of psychological autopsy studies. Evid Based Ment Health. 2022; 25(4):148-155. PMC: 9685708. DOI: 10.1136/ebmental-2022-300549. View

14.

Fucetola R, Seidman L, Kremen W, Faraone S, Goldstein J, Tsuang M . Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers. Biol Psychiatry. 2000; 48(2):137-46. DOI: 10.1016/s0006-3223(00)00240-7. View

15.

Malchow B, Reich-Erkelenz D, Oertel-Knochel V, Keller K, Hasan A, Schmitt A . The effects of physical exercise in schizophrenia and affective disorders. Eur Arch Psychiatry Clin Neurosci. 2013; 263(6):451-67. DOI: 10.1007/s00406-013-0423-2. View

16.

Oertel-Knochel V, Mehler P, Thiel C, Steinbrecher K, Malchow B, Tesky V . Effects of aerobic exercise on cognitive performance and individual psychopathology in depressive and schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2014; 264(7):589-604. DOI: 10.1007/s00406-014-0485-9. View

17.

Suzuki H, Sakuma N, Kobayashi M, Ogawa S, Inagaki H, Edahiro A . Normative Data of the Trail Making Test Among Urban Community-Dwelling Older Adults in Japan. Front Aging Neurosci. 2022; 14:832158. PMC: 9175082. DOI: 10.3389/fnagi.2022.832158. View

18.

Landrigan J, Bell T, Crowe M, Clay O, Mirman D . Lifting cognition: a meta-analysis of effects of resistance exercise on cognition. Psychol Res. 2019; 84(5):1167-1183. DOI: 10.1007/s00426-019-01145-x. View

19.

Sanchez P, Ojeda N, Pena J, Elizagarate E, Yoller A, Gutierrez M . Predictors of longitudinal changes in schizophrenia: the role of processing speed. J Clin Psychiatry. 2009; 70(6):888-96. DOI: 10.4088/JCP.08m04294. View

20.

Girdler S, Confino J, Woesner M . Exercise as a Treatment for Schizophrenia: A Review. Psychopharmacol Bull. 2019; 49(1):56-69. PMC: 6386427. View