Hybrid FeWO-Hyaluronic Acid Nanoparticles As a Targeted Nanotheranostic Agent for Multimodal Imaging-Guided Tumor Photothermal Therapy

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2024 Jan 2

PMID 38164263

Authors

Chunmei Yang

Xiaoling Che

Yu Zhang

Didi Gu

Guidong Dai

Jian Shu

Lu Yang

Affiliations

Soon will be listed here.

Abstract

Background: Development of versatile nanoplatform still remains a great challenge due to multistep synthesis and complicated compositions. Therefore, it is significant to develop a facile method to synthesize a nanocomposite to achieve multimodal imaging and even imaging-guided cancer therapeutics.

Methods And Results: In our study, hyaluronic acid-functionalized iron (II) tungstate nanoparticles (HA-FeWO NPs) were successfully synthesized as a versatile nanoplatform by a facile one-pot hydrothermal procedure. The formed multifunctional HA-FeWO NPs were investigated via a series of characterization techniques, which demonstrated good biocompatibility, excellent dispersion, low cytotoxicity, active tumor-targeting ability and high photothermal efficiency. Furthermore, tumor was clearly visualized by HA-FeWO NPs with multimodal imaging of infrared thermal imaging, magnetic resonance imaging, computed tomography imaging in 4T1 tumor bearing mice. More importantly, HA-FeWO could achieve multimodal imaging-guided photothermal therapy of 4T1 tumors.

Conclusion: The constructed HA-FeWO NPs have great potential as ideal nanotheranostic agents for multimodal imaging and even imaging-guided cancer theranostics in biological systems.

Citing Articles

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The Current Status and Future Directions on Nanoparticles for Tumor Molecular Imaging.

Yin C, Hu P, Qin L, Wang Z, Zhao H Int J Nanomedicine. 2024; 19:9549-9574.

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Targeted Nanotheransotics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases.

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References

Zhou Y, Yao H, Zhang Q, Gong J, Liu S, Yu S . Hierarchical FeWO4 microcrystals: solvothermal synthesis and their photocatalytic and magnetic properties. Inorg Chem. 2009; 48(3):1082-90. DOI: 10.1021/ic801806r. View

Lee S, Jeon S, Jung S, Chung I, Ahn C . Targeted multimodal imaging modalities. Adv Drug Deliv Rev. 2014; 76:60-78. DOI: 10.1016/j.addr.2014.07.009. View

Duan S, Hu Y, Zhao Y, Tang K, Zhang Z, Liu Z . Nanomaterials for photothermal cancer therapy. RSC Adv. 2023; 13(21):14443-14460. PMC: 10172882. DOI: 10.1039/d3ra02620e. View

Poovaragan S, Sundaram R, Magdalane C, Kaviyarasu K, Maaza M . Photocatalytic Activity and Humidity Sensor Studies of Magnetically Reusable FeWO₄-WO₃ Composite Nanoparticles. J Nanosci Nanotechnol. 2018; 19(2):859-866. DOI: 10.1166/jnn.2019.15565. View

Guo T, Lin Y, Zhang W, Hong J, Lin R, Wu X . High-efficiency X-ray luminescence in Eu-activated tungstate nanoprobes for optical imaging through energy transfer sensitization. Nanoscale. 2018; 10(4):1607-1612. DOI: 10.1039/c7nr06405e. View

Jeong H, Lee J, Lee S, Lee J, Cho S . A Transparent Nano-Polycrystalline ZnWO Thin-Film Scintillator for High-Resolution X-ray Imaging. ACS Omega. 2021; 6(48):33224-33230. PMC: 8656202. DOI: 10.1021/acsomega.1c05962. View

Zhao L, Zhang X, Wang X, Guan X, Zhang W, Ma J . Recent advances in selective photothermal therapy of tumor. J Nanobiotechnology. 2021; 19(1):335. PMC: 8543909. DOI: 10.1186/s12951-021-01080-3. View

Soleymani M, Velashjerdi M, Shaterabadi Z, Barati A . One-pot preparation of hyaluronic acid-coated iron oxide nanoparticles for magnetic hyperthermia therapy and targeting CD44-overexpressing cancer cells. Carbohydr Polym. 2020; 237:116130. DOI: 10.1016/j.carbpol.2020.116130. View

Choi K, Han H, Lee E, Shin J, Almquist B, Lee D . Hyaluronic Acid-Based Activatable Nanomaterials for Stimuli-Responsive Imaging and Therapeutics: Beyond CD44-Mediated Drug Delivery. Adv Mater. 2019; 31(34):e1803549. DOI: 10.1002/adma.201803549. View

10.

Zhou B, Xiong Z, Zhu J, Shen M, Tang G, Peng C . PEGylated polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual-mode CT/MR imaging applications. Nanomedicine (Lond). 2016; 11(13):1639-52. DOI: 10.2217/nnm-2016-0093. View

11.

Liu M, Anderson R, Lan X, Conti P, Chen K . Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer. Med Res Rev. 2019; 40(3):909-930. DOI: 10.1002/med.21642. View

12.

Shi H, Qi L, Ma J, Cheng H . Polymer-directed synthesis of penniform BaWO4 nanostructures in reverse micelles. J Am Chem Soc. 2003; 125(12):3450-1. DOI: 10.1021/ja029958f. View

13.

Cheng L, Liu J, Gu X, Gong H, Shi X, Liu T . PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv Mater. 2013; 26(12):1886-93. DOI: 10.1002/adma.201304497. View

14.

Xiao Z, Peng C, Jiang X, Peng Y, Huang X, Guan G . Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy. Nanoscale. 2016; 8(26):12917-28. DOI: 10.1039/c6nr03336a. View

15.

Tan J, Wang X, Li H, Su X, Wang L, Ran L . HYAL1 overexpression is correlated with the malignant behavior of human breast cancer. Int J Cancer. 2010; 128(6):1303-15. DOI: 10.1002/ijc.25460. View

16.

Che X, Yang C, Pan L, Gu D, Dai G, Shu J . Achieving safe and high-performance gastrointestinal tract spectral CT imaging with small-molecule lanthanide complex. Biomater Res. 2023; 27(1):119. PMC: 10664581. DOI: 10.1186/s40824-023-00463-x. View

17.

Liu J, Han J, Kang Z, Golamaully R, Xu N, Li H . In vivo near-infrared photothermal therapy and computed tomography imaging of cancer cells using novel tungsten-based theranostic probe. Nanoscale. 2014; 6(11):5770-6. DOI: 10.1039/c3nr06292a. View

18.

Son J, Yi G, Yoo J, Park C, Koo H, Choi H . Light-responsive nanomedicine for biophotonic imaging and targeted therapy. Adv Drug Deliv Rev. 2018; 138:133-147. PMC: 6547138. DOI: 10.1016/j.addr.2018.10.002. View

19.

Jeong H, Lim H, Lee J, Heo J, Kim H, Cho S . ZnWO Nanoparticle Scintillators for High Resolution X-ray Imaging. Nanomaterials (Basel). 2020; 10(9). PMC: 7559253. DOI: 10.3390/nano10091721. View

20.

Branca M, Pelletier F, Cottin B, Ciuculescu D, Lin C, Serra R . Design of FeBi nanoparticles for imaging applications. Faraday Discuss. 2014; 175:97-111. DOI: 10.1039/c4fd00105b. View