Analysis of the Risk Factors for Negative Emotions in Patients with Esophageal Cancer During the Peri-Radiotherapy Period and Their Effects on Malnutrition

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2024 Jan 1

PMID 38162686

Authors

Feng Luo

Yingying Lu

Chen Chen

Dongdong Chang

Wei Jiang

Ronghua Yin

Affiliations

Soon will be listed here.

Abstract

Background: Esophageal cancer has a high incidence in China. Many patients also have a heavy psychological burden due to clinical features such as wasting and choking on food. This study analyzed the risk factors of negative emotions in esophageal cancer patients during the peri-radiotherapy period and its effects on malnutrition.

Methods: We retrospectively analyzed 339 patients with esophageal cancer during the peri-radiotherapy who received treatment at our hospital from April 2017 to April 2020, and followed up for 3 years. test and Chi-square test were used to analyze the relationship between patients' negative emotions and clinical data. Binary logistics regression was performed to analyze the independent risk factors for the occurrence of negative mood and malnutrition in the patients. Kaplan-Meier survival curves were used to analyze survival rates.

Results: Our results showed that 18.3% of patients undergoing radiotherapy for esophageal cancer had negative emotions, and 41.9% suffered from malnutrition. The results of the binary logistic regression analysis showed that monthly household income (OR = 0.470, P = 0.022), the TNM stage (OR = 2.030, P = 0.044), concomitant gastrointestinal symptoms (OR = 2.071, P = 0.024), sleep status (OR = 2.540, P = 0.003), swallowing disorders (OR = 1.919, P = 0.048), and post-radiotherapy complications were independent risk factors for the development of negative emotions in patients. Negative emotions (OR = 2.547, P = 0.038) were also a risk factor for malnutrition in patients with esophageal cancer.

Conclusion: Many patients with esophageal cancer suffer from anxiety and depression in the peri-radiotherapy period, which might lead to complications such as malnutrition or aggravate and affect the prognosis of patients. Therefore, psychological care should be provided based on conventional care to effectively relieve their psychological pressure, and improve their prognosis and quality of life.

Citing Articles

The Impact of Economic Status on Cause-Specific Survival in Patients with Esophageal Adenocarcinoma in the United States: A Retrospective Analysis.

Xiang X, Li G, Liu J, Gao X, Feng G, Li J Cancer Control. 2024; 31:10732748241303430.

PMID: 39579045 PMC: 11585048. DOI: 10.1177/10732748241303430.

References

Anderluh F, Toplak M, Velenik V, Oblak I, Secerov Ermenc A, Peressutti A . Definitive radiochemotherapy in esophageal cancer - a single institution experience. Radiol Oncol. 2019; 53(4):480-487. PMC: 6884939. DOI: 10.2478/raon-2019-0054. View

Blanar V, Hodl M, Lohrmann C, Amir Y, Eglseer D . Dysphagia and factors associated with malnutrition risk: A 5-year multicentre study. J Adv Nurs. 2019; 75(12):3566-3576. DOI: 10.1111/jan.14188. View

Morgan E, Soerjomataram I, Rumgay H, Coleman H, Thrift A, Vignat J . The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020. Gastroenterology. 2022; 163(3):649-658.e2. DOI: 10.1053/j.gastro.2022.05.054. View

Leger D, Morin C, Uchiyama M, Hakimi Z, Cure S, Walsh J . Chronic insomnia, quality-of-life, and utility scores: comparison with good sleepers in a cross-sectional international survey. Sleep Med. 2011; 13(1):43-51. DOI: 10.1016/j.sleep.2011.03.020. View

Lourenco A, Dantas A, de Souza J, Araujo C, Araujo D, Lima I . Sleep quality is associated with Disability and Quality of life in breast cancer survivors: a cross-sectional pilot study. Eur J Cancer Care (Engl). 2020; :e13339. DOI: 10.1111/ecc.13339. View

Duron V, Bii J, Mutai R, Ngetich J, Harrington D, Parker R . Esophageal cancer awareness in Bomet district, Kenya. Afr Health Sci. 2013; 13(1):122-8. PMC: 3645081. DOI: 10.4314/ahs.v13i1.17. View

Jim H, Jacobsen P, Phillips K, Wenham R, Roberts W, Small B . Lagged relationships among sleep disturbance, fatigue, and depressed mood during chemotherapy. Health Psychol. 2013; 32(7):768-74. PMC: 3700563. DOI: 10.1037/a0031322. View

Savard J, Liu L, Natarajan L, Rissling M, Neikrug A, He F . Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy. Sleep. 2009; 32(9):1155-60. PMC: 2737573. DOI: 10.1093/sleep/32.9.1155. View

Takeda K, Umezawa R, Takahashi N, Matsushita H, Kozumi M, Ishikawa Y . Impact of change in serum albumin level during and after chemoradiotherapy in patients with locally advanced esophageal cancer. Esophagus. 2018; 15(3):190-197. DOI: 10.1007/s10388-018-0612-1. View

10.

Hellstadius Y, Lagergren J, Zylstra J, Gossage J, Davies A, Hultman C . A longitudinal assessment of psychological distress after oesophageal cancer surgery. Acta Oncol. 2017; 56(5):746-752. DOI: 10.1080/0284186X.2017.1287945. View

11.

Wang C, Lu M, Zhou T, Zhao S, Guan S . Intensity-modulated radiotherapy does not decrease the risk of malnutrition in esophageal cancer patients during radiotherapy compared to three-dimensional conformal radiation therapy. J Thorac Dis. 2019; 11(9):3721-3731. PMC: 6790446. DOI: 10.21037/jtd.2019.09.33. View

12.

Holder H . Malnutrition in the elderly: a public health concern. Br J Nurs. 2020; 29(2):118-119. DOI: 10.12968/bjon.2020.29.2.118. View

13.

Song T, Fang M, Wu S . Concurrent chemoradiation therapy tailored to the older adults with esophageal cancer: state of the art and the future. Clin Interv Aging. 2018; 13:2275-2287. PMC: 6233861. DOI: 10.2147/CIA.S179014. View

14.

Savard J, Hervouet S, Ivers H . Prostate cancer treatments and their side effects are associated with increased insomnia. Psychooncology. 2012; 22(6):1381-8. DOI: 10.1002/pon.3150. View

15.

Yang K, Oh D, Noh J, Yoon H, Sun J, Kim H . Feasibility of an Interactive Health Coaching Mobile App to Prevent Malnutrition and Muscle Loss in Esophageal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy: Prospective Pilot Study. J Med Internet Res. 2021; 23(8):e28695. PMC: 8433871. DOI: 10.2196/28695. View

16.

Wang S, Zhang C, Wang Y, Luo K, Yang Y, Yang Y . Risk factors and prognosis for esophageal fistula in patients with esophageal squamous cell carcinoma during radiotherapy. Esophagus. 2022; 19(4):660-669. DOI: 10.1007/s10388-022-00919-4. View

17.

Campbell P, Tang N, McBeth J, Lewis M, Main C, Croft P . The role of sleep problems in the development of depression in those with persistent pain: a prospective cohort study. Sleep. 2013; 36(11):1693-8. PMC: 3792387. DOI: 10.5665/sleep.3130. View

18.

Wang S, Marshall M . Chemoradiation Therapy as Definitive Treatment of Esophageal Cancer. Surg Clin North Am. 2021; 101(3):443-451. DOI: 10.1016/j.suc.2021.03.006. View

19.

Movahed S, Norouzy A, Ghanbari-Motlagh A, Eslami S, Khadem-Rezaiyan M, Emadzadeh M . Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements. Asian Pac J Cancer Prev. 2020; 21(8):2315-2323. PMC: 7771945. DOI: 10.31557/APJCP.2020.21.8.2315. View

20.

Housman B, Flores R, Lee D . Narrative review of anxiety and depression in patients with esophageal cancer: underappreciated and undertreated. J Thorac Dis. 2021; 13(5):3160-3170. PMC: 8182527. DOI: 10.21037/jtd-20-3529. View