» Articles » PMID: 38161868

Futuristic Novel Therapeutic Approaches in the Treatment of Rheumatoid Arthritis

Overview
Journal Cureus
Date 2024 Jan 1
PMID 38161868
Authors
Affiliations
Soon will be listed here.
Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and joint destruction, leading to significant morbidity and reduced quality of life. Although significant progress has been made in the management of RA over the past few decades, many patients still fail to respond adequately to currently available therapies. This article aims to review the current landscape of RA treatment and explore potential novel therapeutic approaches that hold promise for the future. Advances in our understanding of the underlying pathogenesis of the disease have led to the identification of new targets and the development of innovative treatment strategies. This review focuses on emerging therapies including small molecule inhibitors, targeted biologics, cell-based therapies, and gene editing technologies that have shown potential in preclinical and early clinical trials. Additionally, we discuss the challenges and opportunities associated with the use of these new approaches in the treatment of RA. By elucidating the future of novel therapeutic approaches, this article provides insights that can guide clinicians and researchers in their efforts to improve outcomes for patients with RA.

Citing Articles

Safety of Janus kinase inhibitors in rheumatoid arthritis: a disproportionality analysis using FAERS database from 2012 to 2022.

Mikaeili B, Alqahtani Z, Hincapie A, Guo J Clin Rheumatol. 2025; .

PMID: 39945946 DOI: 10.1007/s10067-025-07360-9.

References
1.
Xu Y, Wu Q . Prevalence Trend and Disparities in Rheumatoid Arthritis among US Adults, 2005-2018. J Clin Med. 2021; 10(15). PMC: 8348893. DOI: 10.3390/jcm10153289. View

2.
Volkov M, van Schie K, van der Woude D . Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology. Immunol Rev. 2019; 294(1):148-163. PMC: 7065213. DOI: 10.1111/imr.12829. View

3.
Harden R, McCabe C, Goebel A, Massey M, Suvar T, Grieve S . Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition. Pain Med. 2022; 23(Suppl 1):S1-S53. PMC: 9186375. DOI: 10.1093/pm/pnac046. View

4.
Ahmed S, Jacob B, Carsons S, Leon J, Reiss A . Treatment of Cardiovascular Disease in Rheumatoid Arthritis: A Complex Challenge with Increased Atherosclerotic Risk. Pharmaceuticals (Basel). 2022; 15(1). PMC: 8778152. DOI: 10.3390/ph15010011. View

5.
Wu H, Chen Y, Zhu H, Zhao M, Lu Q . The Pathogenic Role of Dysregulated Epigenetic Modifications in Autoimmune Diseases. Front Immunol. 2019; 10:2305. PMC: 6776919. DOI: 10.3389/fimmu.2019.02305. View