Mitochondrial Fusion-fission Dynamics and Its Involvement in Colorectal Cancer

Overview

Journal Mol Oncol

Specialties Molecular Biology
Oncology

Date 2023 Dec 30

PMID 38158734

Authors

Zihong Wu

Chong Xiao

Fang Li

Wenbo Huang

Fengming You

Xueke Li

Affiliations

Soon will be listed here.

Abstract

The incidence and mortality rates of colorectal cancer have elevated its status as a significant public health concern. Recent research has elucidated the crucial role of mitochondrial fusion-fission dynamics in the initiation and progression of colorectal cancer. Elevated mitochondrial fission or fusion activity can contribute to the metabolic reprogramming of tumor cells, thereby activating oncogenic pathways that drive cell proliferation, invasion, migration, and drug resistance. Nevertheless, excessive mitochondrial fission can induce apoptosis, whereas moderate mitochondrial fusion can protect cells from oxidative stress. This imbalance in mitochondrial dynamics can exert dual roles as both promoters and inhibitors of colorectal cancer progression. This review provides an in-depth analysis of the fusion-fission dynamics and the underlying pathological mechanisms in colorectal cancer cells. Additionally, it offers partial insights into the mitochondrial kinetics in colorectal cancer-associated cells, such as immune and endothelial cells. This review is aimed at identifying key molecular events involved in colorectal cancer progression and highlighting the potential of mitochondrial dynamic proteins as emerging targets for pharmacological intervention.

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References

Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S . Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020; 14(12):3169-3183. PMC: 7718948. DOI: 10.1002/1878-0261.12825. View

Nagashima S, Tabara L, Tilokani L, Paupe V, Anand H, Pogson J . Golgi-derived PI4P-containing vesicles drive late steps of mitochondrial division. Science. 2020; 367(6484):1366-1371. DOI: 10.1126/science.aax6089. View

Xie Y, Chen R, Yan L, Jia Z, Liang G, Wang Q . Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells. Mol Med Rep. 2021; 24(5). PMC: 8456344. DOI: 10.3892/mmr.2021.12437. View

Cui L, Liu P . Two Types of Contact Between Lipid Droplets and Mitochondria. Front Cell Dev Biol. 2021; 8:618322. PMC: 7769837. DOI: 10.3389/fcell.2020.618322. View

He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J . Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nat Commun. 2021; 12(1):4371. PMC: 8285428. DOI: 10.1038/s41467-021-24619-2. View

Zhang B, Zhang L, Chen Y, Qiao X, Zhao S, Li P . Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021; 178(6):1475-1491. DOI: 10.1111/bph.15372. View

Liao M, Sun X, Zheng W, Wu M, Wang Y, Yao J . LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter. Mol Cancer. 2023; 22(1):163. PMC: 10548613. DOI: 10.1186/s12943-023-01859-y. View

Lee J, Westrate L, Wu H, Page C, Voeltz G . Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016; 540(7631):139-143. PMC: 5656044. DOI: 10.1038/nature20555. View

Liskova V, Kajsik M, Chovancova B, Roller L, Krizanova O . Camptothecin, triptolide, and apoptosis inducer kit have differential effects on mitochondria in colorectal carcinoma cells. FEBS Open Bio. 2022; 12(5):913-924. PMC: 9063445. DOI: 10.1002/2211-5463.13401. View

10.

Leo M, Muccillo L, Pranzini E, Barisciano G, Parri M, Lopatriello G . Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality. Cells. 2022; 11(24). PMC: 9776412. DOI: 10.3390/cells11243992. View

11.

Suh J, Kim N, Shim W, Lee S, Kim H, Moon E . Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. Cell Metab. 2023; 35(2):345-360.e7. DOI: 10.1016/j.cmet.2023.01.003. View

12.

Castro-Sepulveda M, Fernandez-Verdejo R, Zbinden-Foncea H, Rieusset J . Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism. Metabolism. 2023; 144:155578. DOI: 10.1016/j.metabol.2023.155578. View

13.

Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I . Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020; 31(5):987-1003.e8. DOI: 10.1016/j.cmet.2020.04.007. View

14.

Zacharioudakis E, Agianian B, Kumar Mv V, Biris N, Garner T, Rabinovich-Nikitin I . Modulating mitofusins to control mitochondrial function and signaling. Nat Commun. 2022; 13(1):3775. PMC: 9262907. DOI: 10.1038/s41467-022-31324-1. View

15.

Wang S, Yang X, Cui S, Gao Z, Qu X . Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med. 2019; 134:87-98. DOI: 10.1016/j.freeradbiomed.2018.12.035. View

16.

Yakobov S, Dhingra R, Margulets V, Dhingra A, Crandall M, Kirshenbaum L . Ellagic acid inhibits mitochondrial fission protein Drp-1 and cell proliferation in cancer. Mol Cell Biochem. 2023; 478(9):2029-2040. DOI: 10.1007/s11010-022-04627-6. View

17.

Tan H, Lu G, Dong H, Cho Y, Natalia A, Wang L . A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nat Commun. 2022; 13(1):3720. PMC: 9240011. DOI: 10.1038/s41467-022-31213-7. View

18.

Zamorano-Leon J, Ballesteros S, de Las Heras N, Alvarez-Sala L, de la Serna-Soto M, Zekri-Nechar K . Effect of Pectin on the Expression of Proteins Associated with Mitochondrial Biogenesis and Cell Senescence in HT29-Human Colorectal Adenocarcinoma Cells. Prev Nutr Food Sci. 2019; 24(2):187-196. PMC: 6615348. DOI: 10.3746/pnf.2019.24.2.187. View

19.

Giacomello M, Pyakurel A, Glytsou C, Scorrano L . The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 2020; 21(4):204-224. DOI: 10.1038/s41580-020-0210-7. View

20.

Li L, Chen Q, Yu Y, Chen H, Lu M, Huang Y . RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics. J Cell Physiol. 2019; 235(1):254-266. DOI: 10.1002/jcp.28965. View