Sjogren's Syndrome: a Neurological Perspective

Overview

Journal Arq Neuropsiquiatr

Publisher Thieme

Specialties Neurology
Psychiatry

Date 2023 Dec 29

PMID 38157875

Authors

Orlando Grazianni Povoas Barsottini

Marianna Pinheiro Moraes de Moraes

Pedro Henrique Almeida Fraiman

Victor Hugo Rocha Marussi

Alexandre Wagner Silva de Souza

Pedro Braga Neto

Mariana Spitz

Affiliations

Soon will be listed here.

Abstract

Sjogren's syndrome (SS) is a complex autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands, resulting in sicca symptoms. Additionally, SS presents with neurological manifestations that significantly impact the nervous system. This review aims to provide a comprehensive overview of the neurological aspects of SSj, covering both the peripheral and central nervous system involvement, while emphasizing diagnosis, treatment, and prognosis.

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References

Gorson K, Ropper A . Positive salivary gland biopsy, Sjögren syndrome, and neuropathy: clinical implications. Muscle Nerve. 2003; 28(5):553-60. DOI: 10.1002/mus.10470. View

Berkowitz A, Samuels M . The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. Pract Neurol. 2013; 14(1):14-22. DOI: 10.1136/practneurol-2013-000651. View

Terrier B, Lacroix C, Guillevin L, Hatron P, Dhote R, Maillot F . Diagnostic and prognostic relevance of neuromuscular biopsy in primary Sjögren's syndrome-related neuropathy. Arthritis Rheum. 2007; 57(8):1520-9. DOI: 10.1002/art.23102. View

Chai J, Herrmann D, Stanton M, Barbano R, Logigian E . Painful small-fiber neuropathy in Sjogren syndrome. Neurology. 2005; 65(6):925-7. DOI: 10.1212/01.wnl.0000176034.38198.f9. View

Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H . The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain. 2005; 128(Pt 11):2518-34. DOI: 10.1093/brain/awh605. View

Baldini C, Pepe P, Quartuccio L, Priori R, Bartoloni E, Alunno A . Primary Sjogren's syndrome as a multi-organ disease: impact of the serological profile on the clinical presentation of the disease in a large cohort of Italian patients. Rheumatology (Oxford). 2013; 53(5):839-44. DOI: 10.1093/rheumatology/ket427. View

Lopate G, Pestronk A, Al-Lozi M, Lynch T, Florence J, Miller T . Peripheral neuropathy in an outpatient cohort of patients with Sjögren's syndrome. Muscle Nerve. 2006; 33(5):672-6. DOI: 10.1002/mus.20514. View

Sahoo D, Dash A, Dey A, Devi S . Myelin oligodendrocyte glycoprotein (MOG) antibody-associated longitudinally extensive transverse myelitis (LETM) and primary Sjogren syndrome: a rare association. BMJ Case Rep. 2023; 15(12). PMC: 9730373. DOI: 10.1136/bcr-2022-249915. View

Seeliger T, Kramer E, Konen F, Zehrfeld N, Beider S, Prenzler N . Sjögren's syndrome with and without neurological involvement. J Neurol. 2023; 270(6):2987-2996. PMC: 10188418. DOI: 10.1007/s00415-023-11613-5. View

10.

Ramos-Casals M, Solans R, Rosas J, Camps M, Gil A, Del Pino-Montes J . Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore). 2008; 87(4):210-219. DOI: 10.1097/MD.0b013e318181e6af. View

11.

Carvalho D, Tironi T, Freitas D, Kleinpaul R, Talim N, Lana-Peixoto M . Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu. Arq Neuropsiquiatr. 2014; 72(8):619-24. DOI: 10.1590/0004-282x20140097. View

12.

Jobling K, Ledingham D, Ng W, Guadagno J . Positive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis. Eur J Rheumatol. 2018; 6(2):102-104. PMC: 6467332. DOI: 10.5152/eurjrheum.2018.18041. View

13.

McCoy S, Baer A . Neurological Complications of Sjögren's Syndrome: Diagnosis and Management. Curr Treatm Opt Rheumatol. 2019; 3(4):275-288. PMC: 6322693. DOI: 10.1007/s40674-017-0076-9. View

14.

Gono T, Kawaguchi Y, Katsumata Y, Takagi K, Tochimoto A, Baba S . Clinical manifestations of neurological involvement in primary Sjögren’s syndrome. Clin Rheumatol. 2010; 30(4):485-90. DOI: 10.1007/s10067-010-1458-7. View

15.

Jaques C, de Moraes M, Silva E, Coimbra-Neto A, Martinez A, Camargos S . Characterisation of ataxia in Sjogren's syndrome. J Neurol Neurosurg Psychiatry. 2020; 91(4):446-448. DOI: 10.1136/jnnp-2019-322373. View

16.

Rodriguez M, Asnal C, Gobbi C, Pellet A, Herscovich N, Amitrano C . Primary Sjögren syndrome and development of another autoimmune rheumatic disease during the follow-up. Adv Rheumatol. 2022; 62(1):19. DOI: 10.1186/s42358-022-00250-7. View

17.

Veenbergen S, Kozmar A, van Daele P, Schreurs M . Autoantibodies in Sjögren's syndrome and its classification criteria. J Transl Autoimmun. 2022; 5:100138. PMC: 8728464. DOI: 10.1016/j.jtauto.2021.100138. View

18.

Delalande S, De Seze J, Fauchais A, Hachulla E, Stojkovic T, Ferriby D . Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore). 2004; 83(5):280-291. DOI: 10.1097/01.md.0000141099.53742.16. View

19.

Vivino F, Bunya V, Massaro-Giordano G, Johr C, Giattino S, Schorpion A . Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment. Clin Immunol. 2019; 203:81-121. DOI: 10.1016/j.clim.2019.04.009. View

20.

Fauchais A, Magy L, Vidal E . Central and peripheral neurological complications of primary Sjögren's syndrome. Presse Med. 2012; 41(9 Pt 2):e485-93. DOI: 10.1016/j.lpm.2012.06.002. View