Synthesis of New Imidazole-based Ionic Liquids with Antifungal Activity Against

Overview

Journal Iran J Microbiol

Publisher Tehran University of Medical Sciences

Specialty Infectious Diseases

Date 2023 Dec 29

PMID 38156299

Authors

Amira Habibi

Mansoura Bayat

Behinb Omidi

Ali Ezabadi

Pejmana Mortazavi

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. This study aimed to investigate the effect of a novel ionic liquid (IL) as a new drug on strains.

Materials And Methods: Seven newly binary ionic liquids mixtures were synthesized, and among them, ([prollinium chloride] [1-methylimidazolium 3-sulfonate] ([pro-HCl][MImS]) was selected and characterized by 1HNMR, 13C NMR, and FT-IR methods. Samples from patients (n=50) with candidiasis were collected and identified through culture media. gene overexpression was related to resistance against azole-bearing drugs. The antibiogram, well diffusion assay, MICs, and MFCs tests were operated. PCR and Real-time evaluated the expression of the gene, and the rate of cell death was detected using Flow Cytometry.

Results: Our data manifested that this novel IL (Ionic Liquid) can inhibit 's growth, reduce the expression of ERG11 and increase dead cells.

Conclusion: The newly synthesized IL had an inhibiting effect on the growth of the strains and may be used as an alternative candidate for novel drug design.

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