Aptamer-functionalized MOFs and AI-driven Strategies for Early Cancer Diagnosis and Therapeutics

Overview

Journal Biotechnol Lett

Specialties Biochemistry
Biotechnology

Date 2023 Dec 28

PMID 38155321

Authors

Abhishek Futane

Pramod Jadhav

Abu Hasnat Mustafa

Arthi Srinivasan

Vigneswaran Narayanamurthy

Affiliations

Soon will be listed here.

Abstract

Metal-Organic Frameworks (MOFs) have exceptional inherent properties that make them highly suitable for diverse applications, such as catalysis, storage, optics, chemo sensing, and biomedical science and technology. Over the past decades, researchers have utilized various techniques, including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasonic, to synthesize MOFs with tailored properties. Post-synthetic modification of linkers, nodal components, and crystallite domain size and morphology can functionalize MOFs to improve their aptamer applications. Advancements in AI and machine learning led to the development of nonporous MOFs and nanoscale MOFs for medical purposes. MOFs have exhibited promise in cancer therapy, with the successful accumulation of a photosensitizer in cancer cells representing a significant breakthrough. This perspective is focused on MOFs' use as advanced materials and systems for cancer therapy, exploring the challenging aspects and promising features of MOF-based cancer diagnosis and treatment. The paper concludes by emphasizing the potential of MOFs as a transformative technology for cancer treatment and diagnosis.

Citing Articles

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References

Albeshan S, Hossain S, Mackey M, Brennan P . Can Breast Self-examination and Clinical Breast Examination Along With Increasing Breast Awareness Facilitate Earlier Detection of Breast Cancer in Populations With Advanced Stages at Diagnosis?. Clin Breast Cancer. 2020; 20(3):194-200. DOI: 10.1016/j.clbc.2020.02.001. View

Cai M, Chen G, Qin L, Qu C, Dong X, Ni J . Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer. Pharmaceutics. 2020; 12(3). PMC: 7150757. DOI: 10.3390/pharmaceutics12030232. View

Campos-Fernandez E, Alqualo N, Moura Garcia L, Coutinho Horacio Alves C, Ferreira Arantes Vieira T, Moreira D . The use of aptamers in prostate cancer: A systematic review of theranostic applications. Clin Biochem. 2021; 93:9-25. DOI: 10.1016/j.clinbiochem.2021.03.014. View

Campuzano S, Yanez-Sedeno P, Pingarron J . Nanoparticles for nucleic-acid-based biosensing: opportunities, challenges, and prospects. Anal Bioanal Chem. 2018; 411(9):1791-1806. DOI: 10.1007/s00216-018-1273-6. View

Capello M, Bantis L, Scelo G, Zhao Y, Li P, Dhillon D . Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer. J Natl Cancer Inst. 2017; 109(4). PMC: 5441297. DOI: 10.1093/jnci/djw266. View

Dey B, Ahmad M, Kim B, Kamal T, Yang D, Patra C . Manganese cobalt-MOF@carbon nanofiber-based non-enzymatic histamine sensor for the determination of food freshness. Anal Bioanal Chem. 2023; 415(17):3487-3501. DOI: 10.1007/s00216-023-04737-0. View

Elskens J, Elskens J, Madder A . Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects. Int J Mol Sci. 2020; 21(12). PMC: 7350236. DOI: 10.3390/ijms21124522. View

Evtugyn G, Belyakova S, Porfireva A, Hianik T . Electrochemical Aptasensors Based on Hybrid Metal-Organic Frameworks. Sensors (Basel). 2020; 20(23). PMC: 7729924. DOI: 10.3390/s20236963. View

Fitzgerald R, Antoniou A, Fruk L, Rosenfeld N . The future of early cancer detection. Nat Med. 2022; 28(4):666-677. DOI: 10.1038/s41591-022-01746-x. View

10.

Futane A, Narayanamurthy V, Jadhav P, Srinivasan A . Aptamer-based rapid diagnosis for point-of-care application. Microfluid Nanofluidics. 2023; 27(2):15. PMC: 9847464. DOI: 10.1007/s10404-022-02622-3. View

11.

He S, Wu L, Li X, Sun H, Xiong T, Liu J . Metal-organic frameworks for advanced drug delivery. Acta Pharm Sin B. 2021; 11(8):2362-2395. PMC: 8424373. DOI: 10.1016/j.apsb.2021.03.019. View

12.

Juskowiak B . Nucleic acid-based fluorescent probes and their analytical potential. Anal Bioanal Chem. 2010; 399(9):3157-76. PMC: 3044240. DOI: 10.1007/s00216-010-4304-5. View

13.

Kalaj M, Cohen S . Postsynthetic Modification: An Enabling Technology for the Advancement of Metal-Organic Frameworks. ACS Cent Sci. 2020; 6(7):1046-1057. PMC: 7379093. DOI: 10.1021/acscentsci.0c00690. View

14.

Khosravan N, Celik H, Turkbey B, Jones E, Wood B, Bagci U . A collaborative computer aided diagnosis (C-CAD) system with eye-tracking, sparse attentional model, and deep learning. Med Image Anal. 2018; 51:101-115. PMC: 6407631. DOI: 10.1016/j.media.2018.10.010. View

15.

Li J, Yu C, Wu Y, Zhu Y, Xu J, Wang Y . Novel sensing platform based on gold nanoparticle-aptamer and Fe-metal-organic framework for multiple antibiotic detection and signal amplification. Environ Int. 2019; 125:135-141. DOI: 10.1016/j.envint.2019.01.033. View

16.

Li J, Liu L, Ai Y, Liu Y, Sun H, Liang Q . Self-Polymerized Dopamine-Decorated Au NPs and Coordinated with Fe-MOF as a Dual Binding Sites and Dual Signal-Amplifying Electrochemical Aptasensor for the Detection of CEA. ACS Appl Mater Interfaces. 2020; 12(5):5500-5510. DOI: 10.1021/acsami.9b19161. View

17.

Liang C, Li F, Wang L, Zhang Z, Wang C, He B . Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma. Biomaterials. 2017; 147:68-85. DOI: 10.1016/j.biomaterials.2017.09.015. View

18.

Liang W, Zhao Y, Huang W, Gao Y, Xu W, Tao J . Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA). Theranostics. 2019; 9(7):2056-2070. PMC: 6485294. DOI: 10.7150/thno.28119. View

19.

Liu J, Huang J, Zhang L, Lei J . Multifunctional metal-organic framework heterostructures for enhanced cancer therapy. Chem Soc Rev. 2020; 50(2):1188-1218. DOI: 10.1039/d0cs00178c. View

20.

Lv M, Zhou W, Tavakoli H, Bautista C, Xia J, Wang Z . Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing. Biosens Bioelectron. 2021; 176:112947. PMC: 7855766. DOI: 10.1016/j.bios.2020.112947. View