ANRIL, H19 and TUG1: a Review About Critical Long Non-coding RNAs in Cardiovascular Diseases

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 Dec 28

PMID 38155319

Authors

Livia da Cunha Agostini

Tamires Cunha Almeida

Glenda Nicioli da Silva

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.

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