Atosiban Application in Fresh ET Cycle is Effective for Women Undergoing Repeated Embryo Implantation Failures, Especially for Advanced-age Obese Patients

Overview

Journal Sci Rep

Specialty Science

Date 2023 Dec 28

PMID 38155160

Authors

Jie Li

Sien Mo

Zhong Lin

Qiuling Shi

Affiliations

Soon will be listed here.

Abstract

To assess the effect of atosiban in pregnancy outcomes of the fresh embryo transfer (ET), the retrospective cohort study was conducted. Six hundred and eighty-nine cases (using atosiban) and 1377 age and ET cycle-matched controls were collected from the January 2016 to May 2022 to perform the fresh IVF-ET cycle. The essential characteristics and pregnancy outcomes were analyzed. Conditional logistic regression analysis and subgroup analysis were performed. In the whole samples, atosiban had no effects in the pregnancy outcomes. Subgroup analyses suggested that atosiban could improve the clinical pregnancy in more than 3 ET cycles (OR 1.667, 95% CI 1.108-2.509, P = 0.014). Moreover, the improvement of clinical pregnancy was mainly present in the advanced-age women (age ≥ 35 years: OR 1.851, 95% CI 1.136-3.014, P = 0.013), obesity (BMI ≥ 24 kg/m: OR 2.550, 95% CI 1.105-5.883, P = 0.028) and cleavage stage embryo (D3 embryo: OR 1.721, 95% CI 1.098-2.696, P = 0.018) among the repeated implantation failures (RIF). Atosiban could also improve the live birth for the obese women. Further, in the RIF, atosiban application was strongly recommended for the advanced-age infertility women, who also had the risk of obesity with the implantation of the cleavage stage embryo. In conclusion, atosiban could improve pregnancy outcomes for the advanced-age and obese women in RIF, especially while implanting the cleavage stage embryo in fresh ET cycle.

Citing Articles

Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study.

Lin P, Chern C, Li C, Lin P, Tsui K, Lin L Reprod Biol Endocrinol. 2024; 22(1):79.

PMID: 38997744 PMC: 11241821. DOI: 10.1186/s12958-024-01255-1.

References

Jwa S, Takamura M, Kuwahara A, Kajihara T, Ishihara O . Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer. Sci Rep. 2021; 11(1):17453. PMC: 8408134. DOI: 10.1038/s41598-021-97044-6. View

Fanchin R, Righini C, Olivennes F, Taylor S, De Ziegler D, Frydman R . Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998; 13(7):1968-74. DOI: 10.1093/humrep/13.7.1968. View

Kim S, Bang J, Fakruzzaman M, Lee K, Ko D, Ghanem N . Effects of flunixin meglumine and prostaglandin F2 α treatments on the development and quality of bovine embryos in vitro. Reprod Domest Anim. 2014; 49(6):957-63. DOI: 10.1111/rda.12413. View

Zegers-Hochschild F, Adamson G, de Mouzon J, Ishihara O, Mansour R, Nygren K . International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009; 92(5):1520-4. DOI: 10.1016/j.fertnstert.2009.09.009. View

Sermondade N, Huberlant S, Bourhis-Lefebvre V, Arbo E, Gallot V, Colombani M . Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis. Hum Reprod Update. 2019; 25(4):439-451. DOI: 10.1093/humupd/dmz011. View

Kask K, Malmgren L, Odensvik K . Prostaglandin F2 alpha metabolite levels following an embryo transfer procedure in the mare. Acta Vet Scand. 1995; 36(1):145-7. PMC: 8095418. View

Richter O, Kubler K, Schmolling J, Kupka M, Reinsberg J, Ulrich U . Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri. Mol Hum Reprod. 2004; 10(5):339-46. DOI: 10.1093/molehr/gah039. View

Chung C, Wong A, Chan C, Saravelos S, Kong G, Cheung L . The changing pattern of uterine contractions before and after fresh embryo transfer and its relation to clinical outcome. Reprod Biomed Online. 2017; 34(3):240-247. DOI: 10.1016/j.rbmo.2016.12.011. View

Wu M, Lin C, Su P, Lai E, Sie F, Mau Y . Atosiban and Pregnancy Outcomes Following In Vitro Fertilization Treatment for Infertile Women Requiring One, Two, or More Embryo Transfer Cycles: A Longitudinal Cohort Study. Reprod Sci. 2020; 27(3):853-859. DOI: 10.1007/s43032-019-00088-3. View

10.

Chen C, Lu F . The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2005; 17 Suppl:1-36. View

11.

Mishra V, Agarwal H, Goel S, Roy P, Choudhary S, Lamba S . A Prospective Case-control Trial to Evaluate and Compare the Efficacy and Safety of Atosiban versus Placebo in Fertilization-embryo Transfer Program. J Hum Reprod Sci. 2018; 11(2):155-160. PMC: 6094537. DOI: 10.4103/jhrs.JHRS_7_17. View

12.

Ombelet W, Cooke I, Dyer S, Serour G, Devroey P . Infertility and the provision of infertility medical services in developing countries. Hum Reprod Update. 2008; 14(6):605-21. PMC: 2569858. DOI: 10.1093/humupd/dmn042. View

13.

Decleer W, Osmanagaoglu K, Devroey P . The role of oxytocin antagonists in repeated implantation -failure. Facts Views Vis Obgyn. 2014; 4(4):227-9. PMC: 3987474. View

14.

Ayoubi J, Epiney M, Brioschi P, Fanchin R, Chardonnens D, de Ziegler D . Comparison of changes in uterine contraction frequency after ovulation in the menstrual cycle and in in vitro fertilization cycles. Fertil Steril. 2003; 79(5):1101-5. DOI: 10.1016/s0015-0282(03)00179-1. View

15.

Snider A, Wood J . Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction. 2019; 158(3):R79-R90. DOI: 10.1530/REP-18-0583. View

16.

Tang C, Li Q, Chen F, Cai C, Dong Y, Wu Y . A randomized double blind comparison of atosiban in patients with recurrent implantation failure undergoing IVF treatment. Reprod Biol Endocrinol. 2022; 20(1):124. PMC: 9389813. DOI: 10.1186/s12958-022-00999-y. View

17.

Moraloglu O, Tonguc E, Var T, Zeyrek T, Batioglu S . Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF. Reprod Biomed Online. 2010; 21(3):338-43. DOI: 10.1016/j.rbmo.2010.04.009. View

18.

Zarei A, Mahboubi M, Parsanezhad M, Alborzi S, Younesi M, Madadi G . Effects of piroxicam administration on pregnancy outcome in intrauterine insemination (IUI) cycles: a randomized clinical trial. Clin Exp Obstet Gynecol. 2016; 43(2):225-9. View

19.

Li J, Chen Y, Wang A, Zhang H . A meta-analysis of atosiban supplementation among patients undergoing assisted reproduction. Arch Gynecol Obstet. 2017; 296(4):623-634. DOI: 10.1007/s00404-017-4455-0. View

20.

Kiguchi K, Kido A, Kataoka M, Shitano F, Fujimoto K, Himoto Y . Uterine peristalsis and junctional zone: correlation with age and postmenopausal status. Acta Radiol. 2016; 58(2):224-231. DOI: 10.1177/0284185116639768. View