Plasma MiRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2023 Dec 28

PMID 38153877

Authors

Pandora L Wander

Theo K Bammler

James W MacDonald

Sengeo Srinouanprachanh

Edward J Boyko

Daniel A Enquobahrie

Affiliations

Soon will be listed here.

Abstract

Objective: To identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D).

Research Design And Methods: We examined whether a panel of miRNAs could predict treatment failure in training/test data sets among participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study (N = 209). We also examined whether individual miRNAs were associated with treatment failure.

Results: Participants were age 14.5 years, and 62% were female. A panel of miRNAs did not predict treatment failure. However, for each doubling, miR-4306 was associated with a 12% decrease (P = 0.040) and miR-483-3p was marginally associated with a 12% increase (P = 0.080) in failure independently of sex, race/ethnicity, BMI, Tanner stage, HbA1c, maternal diabetes, oral disposition index, and treatment arm. The addition of both miRNAs improved model fit (log likelihood without vs. with miRNAs -360.3 vs. -363.5; P = 0.040).

Conclusions: miR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.

Citing Articles

Circulating MicroRNAs as Predictors of Beta Cell Function in Youth-onset Type 2 Diabetes: The TODAY Study.

Redling D, Bialak S, El Ghormli L, Chernausek S, Jones K, Tryggestad J J Clin Endocrinol Metab. 2024; 109(12):3027-3035.

PMID: 38815053 PMC: 11570374. DOI: 10.1210/clinem/dgae376.

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