[Clinical and Microbiological Characteristics of Urinary Tract Infections in the First Year After Renal Transplantation]

Overview

Journal Rev Fac Cien Med Univ Nac Cordoba

Specialty General Medicine

Date 2023 Dec 27

PMID 38150202

Authors

Paula Vilella

Juan Pablo Maldonado

Pehuen Fernandez

Maria Fernanda Flores

Camila De Bernardi

Karen Y Vilte Velazquez

Daniela Hernandez

Jorge Luis De La Fuente

Emanuel Jose Saad

Affiliations

Soon will be listed here.

Abstract

Introduction: Urinary tract infections (UTI) are the most frequent infection in kidney transplant (KT) patients. The main objective was to determine the clinical and microbiological characteristics of UTIs that occur during the first year after KT.

Methods: Retrospective cohort study that included patients over 18 years of age who received KT between 2009-2020 in two hospitals in Córdoba city, Argentina. Patients were followed up during the first year after the transplant by recording them in the medical records, and those who presented at least one episode of UTI were analyzed.

Results: During the study period, 568 KTs were performed, of which 207 (36.4%) had at least one episode of UTI. In total, there were 419 UTI episodes, 6 (1.4%) polymicrobial UTI episodes, so a total of 426 microorganisms were identified in the urine cultures. Of the total number of episodes, 206 (49.2%) occurred between 31 and 180 days post-transplant. The main etiological agent was E. coli with 225 isolates (52.8%) followed by Klebsiella sp. with 94 (22.1%). 52.1% of all episodes were caused by multi-resistant microorganisms (MRM). Among the E. coli isolates, 94 (41.8%) were MRM. In the multivariate analysis, the risk factors associated with UTI due to MRM were a history of recurrent UTI (Odds ratio 2.43; 95% CI: 1.37-4.30) and induction with basiliximab (Odds ratio 1.53; 95% CI: 1.029-2.29).

Main Conclusion: UTIs occurred in more than a third of kidney transplant patients, being slightly more than half caused by MOR.

Citing Articles

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