Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Dec 23

PMID 38139201

Authors

Jaehyeong Kim

Sooun Kwak

Juhyun Lee

Il-Ho Park

Seung Hoon Lee

Jae Min Shin

Tae Hoon Kim

Affiliations

Soon will be listed here.

Abstract

Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, and eosinophilic CRS (eCRS) is a subtype characterized by significant eosinophil infiltration and immune response by T-helper-2 cells. The pathogenesis of eCRS is heterogeneous and involves various environmental and host factors. Proteases from external sources, such as mites, fungi, and bacteria, have been implicated in inducing type 2 inflammatory reactions. The balance between these proteases and endogenous protease inhibitors (EPIs) is considered important, and their imbalance can potentially lead to type 2 inflammatory reactions, such as eCRS. In this review, we discuss various mechanisms by which exogenous proteases influence eCRS and highlight the emerging role of endogenous protease inhibitors in eCRS pathogenesis.

Citing Articles

Rat nasal mucosa-derived ectodermal mesenchymal stem cells: A new therapeutic option for chronic rhinosinusitis.

Li L, Liu Z, Zhang C, Long Y, Yang T Immun Inflamm Dis. 2024; 12(7):e1337.

PMID: 39023421 PMC: 11256880. DOI: 10.1002/iid3.1337.

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