The Role of Neutrophils in ANCA-Associated Vasculitis: The Pathogenic Role and Diagnostic Utility of Autoantibodies

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Dec 23

PMID 38139045

Authors

Agata Walulik

Kinga Lysak

Michal Blaszkiewicz

Ignacy Gorecki

Krzysztof Gomulka

Affiliations

Soon will be listed here.

Abstract

Recent years have brought progress in understanding the role of the neutrophil, dispelling the dogma of homogeneous cells mainly involved in the prime defence against pathogens, shedding light on their pathogenic role in inflammatory diseases and on the importance of antineutrophil-cytoplasmic antibodies' pathogenic role in ANCA-associated vasculitides vasculitis (AAV). Myeloperoxidase (MPO) and proteinase 3 (PR3) expressed in neutrophil granulocytes are the most common targets for ANCAs and contribute to the formation of MPO-ANCAs and PR3-ANCAs which, released to the bloodstream, become an excellent diagnostic tool for AAV. In this study, we focus on increasing the clinical and experimental evidence that supports the pathogenic role of ANCAs in AAV. Additionally, we discuss the diagnostic utility of ANCAs for disease activity and prognosis in AAV. Understanding the central role of ANCAs in AAV is crucial for advancing our knowledge of these complex disorders and developing targeted therapeutic strategies in the era of personalized medicine.

Citing Articles

Childhood-Onset ANCA-Associated Vasculitis: From Genetic Studies to Advances in Pathogenesis, Classification and Novel Therapeutic Approaches.

Yeo L, Naheed A, Richards C, Ciurtin C Int J Mol Sci. 2025; 25(24.

PMID: 39769465 PMC: 11676361. DOI: 10.3390/ijms252413704.

ANCA-Positive Small-Vessel Vasculitis Following SARS-CoV-2 Vaccination-A Systematic Review.

Lysak K, Walulik A, Blaszkiewicz M, Gomulka K Vaccines (Basel). 2024; 12(6).

PMID: 38932385 PMC: 11209111. DOI: 10.3390/vaccines12060656.

Pathogenesis of Pulmonary Manifestations in ANCA-Associated Vasculitis and Goodpasture Syndrome.

Fouka E, Drakopanagiotakis F, Steiropoulos P Int J Mol Sci. 2024; 25(10).

PMID: 38791316 PMC: 11121030. DOI: 10.3390/ijms25105278.

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