Stress and Right Prefrontal Transcranial Direct Current Stimulation (tDCS) Interactive Effects on Visual Working Memory and Learning

Overview

Journal Brain Sci

Publisher MDPI

Date 2023 Dec 23

PMID 38137090

Authors

Yael L E Ankri

Yoram C Braw

Oded Meiron

Affiliations

Soon will be listed here.

Abstract

Stress impacts prefrontal cortex (PFC) activity and modulates working memory performance. In a recent study, stimulating the dorsolateral PFC (dlPFC) using transcranial direct current stimulation (tDCS) interacted with social stress in modulating participants' working memory. More specifically, stress disrupted the enhancing effects of dlPFC tDCS on working memory performance. The current study aimed to further explore these initial findings by randomizing healthy females to four experimental conditions ( = 130); stimulation (right dlPFC tDCS vs. sham) and (social stress vs. control). Participants performed cognitive tasks (i.e., visual working memory task and a visual declarative memory task) at baseline and post-stimulation. They also completed self-report measures of stress and anxiety. A significant × interaction was evident in the declarative memory (One-Card Learning, OCL) task, while working memory performance was unaffected. Though tDCS stimulation and stress did not interact to affect working memory, further research is warranted as these initial findings suggest that immediate visual-memory learning may be affected by these factors. The limited number of earlier studies, as well as the variability in their designs, provides additional impetus for studying the interactive effects of stress and tDCS on human visual learning.

References

Farhat L, Carvalho A, Solmi M, Brunoni A . Evidence-based umbrella review of cognitive effects of prefrontal tDCS. Soc Cogn Affect Neurosci. 2020; 17(1):43-60. PMC: 8866814. DOI: 10.1093/scan/nsaa084. View

Mustafa A, Woods S, Loft S, Morgan E . Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study. J Int Neuropsychol Soc. 2023; 29(7):677-685. PMC: 10801707. DOI: 10.1017/S1355617722000698. View

Stricker N, Lundt E, Albertson S, Machulda M, Pudumjee S, Kremers W . Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer's Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment. J Alzheimers Dis. 2020; 76(1):261-274. PMC: 7546579. DOI: 10.3233/JAD-200087. View

Meiron O, Hermesh H, Katz N, Weizman A . Executive attention deficits in schizophrenia: putative mandatory and differential cognitive pathology domains in medicated schizophrenia patients. Psychiatry Res. 2012; 209(1):1-8. DOI: 10.1016/j.psychres.2012.09.057. View

Gaab J, Rohleder N, Nater U, Ehlert U . Psychological determinants of the cortisol stress response: the role of anticipatory cognitive appraisal. Psychoneuroendocrinology. 2005; 30(6):599-610. DOI: 10.1016/j.psyneuen.2005.02.001. View

Schoofs D, Preuss D, Wolf O . Psychosocial stress induces working memory impairments in an n-back paradigm. Psychoneuroendocrinology. 2008; 33(5):643-53. DOI: 10.1016/j.psyneuen.2008.02.004. View

Medina J, Cason S . No evidential value in samples of transcranial direct current stimulation (tDCS) studies of cognition and working memory in healthy populations. Cortex. 2017; 94:131-141. DOI: 10.1016/j.cortex.2017.06.021. View

OKeeffe K, Hodder S, Lloyd A . A comparison of methods used for inducing mental fatigue in performance research: individualised, dual-task and short duration cognitive tests are most effective. Ergonomics. 2019; 63(1):1-12. DOI: 10.1080/00140139.2019.1687940. View

Ciullo V, Spalletta G, Caltagirone C, Banaj N, Vecchio D, Piras F . Transcranial Direct Current Stimulation and Cognition in Neuropsychiatric Disorders: Systematic Review of the Evidence and Future Directions. Neuroscientist. 2020; 27(3):285-309. DOI: 10.1177/1073858420936167. View

10.

Nixon G, Sarant J, Tomlin D, Dowell R . Hearing Aid Uptake, Benefit, and Use: The Impact of Hearing, Cognition, and Personal Factors. J Speech Lang Hear Res. 2021; 64(2):651-663. DOI: 10.1044/2020_JSLHR-20-00014. View

11.

Brunoni A, Vanderhasselt M . Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: a systematic review and meta-analysis. Brain Cogn. 2014; 86:1-9. DOI: 10.1016/j.bandc.2014.01.008. View

12.

Faul F, Erdfelder E, Buchner A, Lang A . Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009; 41(4):1149-60. DOI: 10.3758/BRM.41.4.1149. View

13.

Tuerk C, Saha T, Bouchard M, Booij L . Computerized Cognitive Test Batteries for Children and Adolescents-A Scoping Review of Tools For Lab- and Web-Based Settings From 2000 to 2021. Arch Clin Neuropsychol. 2023; 38(8):1683-1710. PMC: 10681451. DOI: 10.1093/arclin/acad039. View

14.

Cromer J, Schembri A, Harel B, Maruff P . The nature and rate of cognitive maturation from late childhood to adulthood. Front Psychol. 2015; 6:704. PMC: 4445246. DOI: 10.3389/fpsyg.2015.00704. View

15.

Fitzgerald P, Maller J, Hoy K, Thomson R, Daskalakis Z . Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments. Brain Stimul. 2010; 2(4):234-7. DOI: 10.1016/j.brs.2009.03.002. View

16.

Sicard V, Stephenson D, Hergert D, Dodd A, Robertson-Benta C, Pabbathi Reddy S . Investigating the diagnostic accuracy of a paper-and-pencil and a computerized cognitive test battery for pediatric mild traumatic brain injury. Neuropsychology. 2022; 36(6):565-577. PMC: 9900695. DOI: 10.1037/neu0000803. View

17.

Labuschagne I, Grace C, Rendell P, Terrett G, Heinrichs M . An introductory guide to conducting the Trier Social Stress Test. Neurosci Biobehav Rev. 2019; 107:686-695. DOI: 10.1016/j.neubiorev.2019.09.032. View

18.

Mancuso L, Ilieva I, Hamilton R, Farah M . Does Transcranial Direct Current Stimulation Improve Healthy Working Memory?: A Meta-analytic Review. J Cogn Neurosci. 2016; 28(8):1063-89. DOI: 10.1162/jocn_a_00956. View

19.

Arnsten A . Stress weakens prefrontal networks: molecular insults to higher cognition. Nat Neurosci. 2015; 18(10):1376-85. PMC: 4816215. DOI: 10.1038/nn.4087. View

20.

Berryhill M, Peterson D, Jones K, Stephens J . Hits and misses: leveraging tDCS to advance cognitive research. Front Psychol. 2014; 5:800. PMC: 4111100. DOI: 10.3389/fpsyg.2014.00800. View