Neglected Populations Not to Be Forgotten: Tackling Antimicrobial Resistance in Neonatal Infections

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2023 Dec 23

PMID 38136722

Authors

Lucia Barcellini

Ilia Bresesti

Laura Folgori

Affiliations

Soon will be listed here.

Abstract

Making further progress in reducing child mortality hinges on lowering the annual count of neonatal deaths; currently, this stands at 2 [...].

References

Dickerman B, Garcia-Albeniz X, Logan R, Denaxas S, Hernan M . Avoidable flaws in observational analyses: an application to statins and cancer. Nat Med. 2019; 25(10):1601-1606. PMC: 7076561. DOI: 10.1038/s41591-019-0597-x. View

Trevisi L, Hernan M, Mitnick C, Khan U, Seung K, Rich M . Effectiveness of Bedaquiline Use beyond Six Months in Patients with Multidrug-Resistant Tuberculosis. Am J Respir Crit Care Med. 2023; 207(11):1525-1532. PMC: 10263131. DOI: 10.1164/rccm.202211-2125OC. View

Russell N, Barday M, Okomo U, Dramowski A, Sharland M, Bekker A . Early-versus late-onset sepsis in neonates - time to shift the paradigm?. Clin Microbiol Infect. 2023; 30(1):38-43. DOI: 10.1016/j.cmi.2023.07.023. View

Brocklehurst P, Farrell B, King A, Juszczak E, Darlow B, Haque K . Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011; 365(13):1201-11. DOI: 10.1056/NEJMoa1100441. View

Chai G, Governale L, McMahon A, Trinidad J, Staffa J, Murphy D . Trends of outpatient prescription drug utilization in US children, 2002-2010. Pediatrics. 2012; 130(1):23-31. DOI: 10.1542/peds.2011-2879. View

Williams P, Qazi S, Agarwal R, Velaphi S, Bielicki J, Nambiar S . Antibiotics needed to treat multidrug-resistant infections in neonates. Bull World Health Organ. 2022; 100(12):797-807. PMC: 9706347. DOI: 10.2471/BLT.22.288623. View

. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019; 393(10170):423-433. PMC: 6356450. DOI: 10.1016/S0140-6736(18)32221-9. View

Laxminarayan R, Matsoso P, Pant S, Brower C, Rottingen J, Klugman K . Access to effective antimicrobials: a worldwide challenge. Lancet. 2015; 387(10014):168-75. DOI: 10.1016/S0140-6736(15)00474-2. View

Folgori L, Bielicki J, Heath P, Sharland M . Antimicrobial-resistant Gram-negative infections in neonates: burden of disease and challenges in treatment. Curr Opin Infect Dis. 2017; 30(3):281-288. DOI: 10.1097/QCO.0000000000000371. View

10.

Gershon A, Lindenauer P, Wilson K, Rose L, Walkey A, Sadatsafavi M . Informing Healthcare Decisions with Observational Research Assessing Causal Effect. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021; 203(1):14-23. PMC: 7781125. DOI: 10.1164/rccm.202010-3943ST. View

11.

Hernan M, Robins J . Estimating causal effects from epidemiological data. J Epidemiol Community Health. 2006; 60(7):578-86. PMC: 2652882. DOI: 10.1136/jech.2004.029496. View

12.

Schunemann H, Tugwell P, Reeves B, Akl E, Santesso N, Spencer F . Non-randomized studies as a source of complementary, sequential or replacement evidence for randomized controlled trials in systematic reviews on the effects of interventions. Res Synth Methods. 2015; 4(1):49-62. DOI: 10.1002/jrsm.1078. View

13.

Okomo U, Akpalu E, Le Doare K, Roca A, Cousens S, Jarde A . Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines. Lancet Infect Dis. 2019; 19(11):1219-1234. DOI: 10.1016/S1473-3099(19)30414-1. View

14.

Hernan M, Wang W, Leaf D . Target Trial Emulation: A Framework for Causal Inference From Observational Data. JAMA. 2022; 328(24):2446-2447. DOI: 10.1001/jama.2022.21383. View

15.

Wen S, Ezure Y, Rolley L, Spurling G, Lau C, Riaz S . Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Med. 2021; 18(9):e1003787. PMC: 8478175. DOI: 10.1371/journal.pmed.1003787. View

16.

Hayes R, Hartnett J, Semova G, Murray C, Murphy K, Carroll L . Neonatal sepsis definitions from randomised clinical trials. Pediatr Res. 2021; 93(5):1141-1148. PMC: 10132965. DOI: 10.1038/s41390-021-01749-3. View

17.

Hernan M . Methods of Public Health Research - Strengthening Causal Inference from Observational Data. N Engl J Med. 2021; 385(15):1345-1348. DOI: 10.1056/NEJMp2113319. View

18.

Downie L, Armiento R, Subhi R, Kelly J, Clifford V, Duke T . Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO's currently recommended antibiotics--systematic review and meta-analysis. Arch Dis Child. 2012; 98(2):146-54. DOI: 10.1136/archdischild-2012-302033. View

19.

Seymour C, Liu V, Iwashyna T, Brunkhorst F, Rea T, Scherag A . Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8):762-74. PMC: 5433435. DOI: 10.1001/jama.2016.0288. View

20.

Sands K, Carvalho M, Portal E, Thomson K, Dyer C, Akpulu C . Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries. Nat Microbiol. 2021; 6(4):512-523. PMC: 8007471. DOI: 10.1038/s41564-021-00870-7. View