Three-dimensional Thermophotonic Super-resolution Imaging by Spatiotemporal Diffusion Reversal Method

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2023 Dec 22

PMID 38134277

Authors

Damber Thapa

Pantea Tavakolian

George Zhou

Alan Zhang

Asser Abdelgawad

Elnaz Baradaran Shokouhi

Koneswaran Sivagurunathan

Andreas Mandelis

Affiliations

Soon will be listed here.

Abstract

Spatial super-resolution in thermophotonic imaging was achieved using a combination of spatial second-derivative forming, spatial gradient adaptive filtering, and Richardson-Lucy deconvolution in conjunction with the construction of an experimental point spread function. When implemented through enhanced truncation-correlation photothermal coherence tomography (eTC-PCT), it was possible to restore blurred infrared thermophotonic images to their prediffusion optical resolution state. This modality was tested in various biological applications and proved to be capable of imaging fine axial cracks in human teeth, well-patterned anatomical subsurface structures of a mouse brain, and neovascularization in a mouse thigh due to the rapid proliferation of cancer cells. This modality was found to be immune to optical scattering and could reveal the true spatial extent of biological features at subsurface depths that conventional thermal imaging cannot reach because of limitations imposed by the physics of spreading diffusion.

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