Potentiation of the Chemotherapeutic Action of 5-fluorouracil by Combination with Cytidine or Guanosine on HRS-sarcoma

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1979 Apr 12

PMID 381315

Citations 4

Authors

H Osswald

M Youssef

Affiliations

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Abstract

The chemotherapeutic action of 5-fluorouracil monotherapy on HRS-Sarcoma in mice was compared with those of 5-fluorouracil nucleoside combinations (thymidine, cytidine or guanosine). The curative action of 5-fluorouracil was potentiated without increasing its toxicity, when cytidine or guanosine were applied at definite intervals before or after 5-fluorouracil.

Citing Articles

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Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.

Iigo M, Hoshi A Cancer Chemother Pharmacol. 1984; 13(2):86-90.

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Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate.

Iigo M, Yamaizumi Z, Nishimura S, Hoshi A Cancer Chemother Pharmacol. 1987; 20(1):1-4.

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Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.

HARTMANN H, BOLLAG W Med Oncol Tumor Pharmacother. 1986; 3(2):111-8.

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