Capillary Leak Syndrome Within an Hour of G-CSF

Overview

Journal J Pediatr Pharmacol Ther

Specialty Pediatrics

Date 2023 Dec 22

PMID 38130499

Authors

Pallavi Agarwal

Aashima Pandhi

Amanda Strobel

Janesha Thomas

Jeffrey Schwartz

Affiliations

Soon will be listed here.

Abstract

Capillary leak syndrome (CLS) is a well-known phenomenon that has been reported commonly in association with septic shock, polytrauma, and pancreatitis in intensive care settings. In the hematologic literature, it has been reported following granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, tumor necrosis factor, interleukin 2, and interleukin 4 infusions; and autologous and allogenic bone marrow transplantations in both pediatric as well as adult populations. Only a few cases of CLS have been reported in the pediatric population following G-CSF. We report here a case of a 9-year-old female who developed CLS within 60 minutes of receiving the first dose of G-CSF that was successfully treated with immediate symptomatic management.

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