Predictors of Successful Extubation from Volume-targeted Ventilation in Extremely Preterm Neonates

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2023 Dec 20

PMID 38123799

Authors

Dimitrios Rallis

Danielle Ben-David

Kendra Woo

Jill Robinson

David Beadles

Fotios Spyropoulos

Helen Christou

Sule Cataltepe

Affiliations

Soon will be listed here.

Abstract

Objective: To identify variables associated with extubation success in extremely preterm neonates extubated from invasive volume-targeted ventilation.

Study Design: We retrospectively evaluated 84 neonates ≤28 weeks' gestational age, on their first elective extubation. The primary outcome of successful extubation was defined as non-reintubation within seven days. We used multivariate logistic regression analysis.

Results: We identified 58 (69%) neonates (mean gestational age of 26.5 ± 1.4 weeks, birthweight 921 ± 217 g) who met the primary outcome. Female sex (OR 1.15, 95% CI 1.01-9.10), higher pre-extubation weight (OR 1.29, 95% CI 1.05-1.59), and pH (OR 2.54, 95% CI 1.54-4.19), and lower pre-extubation mean airway pressure (MAP) (OR 0.49, 95% CI 0.33-0.73) were associated with successful extubation.

Conclusions: In preterm neonates, female sex, higher pre-extubation weight and pH, and lower pre-extubation MAP were predictors of successful extubation from volume-targeted ventilation. Evaluation of these variables will likely assist clinicians in selecting the optimal time for extubation in such vulnerable neonates.

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