Quantifying Iodine Concentration in the Normal Bowel Wall Using Dual-energy CT: Influence of Patient and Contrast Characteristics

Overview

Journal Sci Rep

Specialty Science

Date 2023 Dec 20

PMID 38123632

Authors

Majida Nehnahi

Gabriel Simon

Romain Moinet

Gael Piton

Camille Camelin

Maxime Ronot

Eric Delabrousse

Paul Calame

Affiliations

Soon will be listed here.

Abstract

This study aimed to establish quantitative references of the normal bowel wall iodine concentration (BWIC) using dual energy CT (DECT). This single-center retrospective study included 248 patients with no history of gastrointestinal disease who underwent abdominal contrast-enhanced DECT between January and April 2022. The BWIC was normalized by the iodine concentration of upper abdominal organs (BWIC) and the iodine concentration (IC) of the aorta (BWIC). BWIC decreased from the stomach to the rectum (mean 2.16 ± 0.63 vs. 2.19 ± 0.63 vs. 2.1 ± 0.58 vs. 1.67 ± 0.47 vs. 1.31 ± 0.4 vs. 1.18 ± 0.34 vs. 0.94 ± 0.26 mgI/mL for the stomach, duodenum, jejunum, ileum, right colon, left colon and rectum, respectively; P < 0.001). By multivariate analysis, BWIC was associated with a higher BMI (OR:1.01, 95% CI 1.00-1.02, P < 0.001) and with a higher injected contrast dose (OR: 1.51; 95% CI 1.36-1.66, P < 0.001 and 2.06; 95% CI 1.88-2.26, P < 0.001 for 500 mgI/kg and 600 mgI/kg doses taking 400 mgI/kg dose as reference). The BWIC was shown independent from patients and contrast-related variables while the BWIC was not. BWIC varies according to bowel segments and is dependent on the total iodine dose injected. It shall be normalized with the IC of the upper abdominal organs.

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