The Photobiomodulation Effect of 980 nm Diode Laser on Patients with Xerostomia

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2023 Dec 20

PMID 38117359

Authors

Nahid Derikvand

Maryam Basirat

Seyedeh Sara Ghasemi

Reza Hashemi

Affiliations

Soon will be listed here.

Abstract

Purpose: Xerostomia is not a disease in itself. This condition is associated with systemic diseases, medication use, and radiotherapy. Oral and general health suffer when the salivary gland´s function is reduced. The effectiveness of therapeutic methods in resolving this issue thus far has been inadequate. This study aimed to determine the photobiomodulation (PBM) effect of a 980 nm laser on xerostomia.

Methods: A quasi-experimental study was carried out using a 980 nm diode laser on 28 patients with xerostomia. A diode laser (980 nm) was used extortionally over the submandibular glands and parotids and it was used internally in the sublingual glands. The laser beam (extrorally 6 J, 300mW, 20 s, and introrally 4 J, 200mW, 20 s) was applied bilaterally every other day for 10 sessions. It should be noted that 8 points of the parotid, 2 points of the submandibular glands, and 2 points of the sublingual glands were irradiated. The saliva was collected each session using the Navazesh technique, 5 min before and after PBM. The Wilcoxon test was used to study the effect of laser therapy on saliva flow rate (volume and weight). The P < 0.05 level was considered a significant level.

Results: The volume (P < 0.0001) and the weight (P < 0.0001) of the saliva were increased by using a 980 nm diode laser. While, in smokers and diabetic patients with hypertension, no significant difference was observed in either saliva volume (P = 0.593, P = 0.092) or weight (P = 0.785, P = 0.089).

Conclusion: In this study, the volume and weight of the unstimulated saliva in most patients with xerostomia increased with using PBM.

References

Loncar B, Stipetic M, Baricevic M, Risovic D . The effect of low-level laser therapy on salivary glands in patients with xerostomia. Photomed Laser Surg. 2010; 29(3):171-5. DOI: 10.1089/pho.2010.2792. View

Wollina U . Three Hundred Patients Treated with Ultrapulsed 980 nm Diode Laser for Skin Disorders. Indian J Dermatol. 2016; 61(5):540-4. PMC: 5029241. DOI: 10.4103/0019-5154.190111. View

Ahrar K, Gowda A, Javadi S, Borne A, Fox M, McNichols R . Preclinical assessment of a 980-nm diode laser ablation system in a large animal tumor model. J Vasc Interv Radiol. 2010; 21(4):555-61. PMC: 2847585. DOI: 10.1016/j.jvir.2010.01.002. View

de Almeida P, Gregio A, Machado M, de Lima A, Azevedo L . Saliva composition and functions: a comprehensive review. J Contemp Dent Pract. 2008; 9(3):72-80. View

Ash C, Dubec M, Donne K, Bashford T . Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods. Lasers Med Sci. 2017; 32(8):1909-1918. PMC: 5653719. DOI: 10.1007/s10103-017-2317-4. View

Farivar S, Malekshahabi T, Shiari R . Biological effects of low level laser therapy. J Lasers Med Sci. 2015; 5(2):58-62. PMC: 4291815. View

Onizawa K, Muramatsu T, Matsuki M, Ohta K, Matsuzaka K, Oda Y . Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland. Lasers Med Sci. 2008; 24(2):155-61. DOI: 10.1007/s10103-008-0541-7. View

Simoes A, Ganzerla E, Yamaguti P, Eduardo C, Nicolau J . Effect of diode laser on enzymatic activity of parotid glands of diabetic rats. Lasers Med Sci. 2008; 24(4):591-6. DOI: 10.1007/s10103-008-0619-2. View

Terlevic Dabic D, Jurisic S, Vucicevic Boras V, Gabric D, Bago I, Vrdoljak D . The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study. Photomed Laser Surg. 2016; 34(9):389-93. DOI: 10.1089/pho.2016.4109. View

10.

Villa A, Connell C, Abati S . Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag. 2015; 11:45-51. PMC: 4278738. DOI: 10.2147/TCRM.S76282. View

11.

Ship J, Fischer D . The relationship between dehydration and parotid salivary gland function in young and older healthy adults. J Gerontol A Biol Sci Med Sci. 1997; 52(5):M310-9. DOI: 10.1093/gerona/52a.5.m310. View

12.

Mese H, Matsuo R . Salivary secretion, taste and hyposalivation. J Oral Rehabil. 2007; 34(10):711-23. DOI: 10.1111/j.1365-2842.2007.01794.x. View

13.

Simoes A, Platero M, Campos L, Aranha A, Eduardo C, Nicolau J . Laser as a therapy for dry mouth symptoms in a patient with Sjögren's syndrome: a case report. Spec Care Dentist. 2009; 29(3):134-7. DOI: 10.1111/j.1754-4505.2009.00078.x. View

14.

Saleh J, Figueiredo M, Cherubini K, Salum F . Salivary hypofunction: an update on aetiology, diagnosis and therapeutics. Arch Oral Biol. 2014; 60(2):242-55. DOI: 10.1016/j.archoralbio.2014.10.004. View

15.

Elavarasu S, Thangavelu A, Alex S . Comparative evaluation of depigmentation techniques in split-mouth design with electrocautery and laser. J Pharm Bioallied Sci. 2015; 7(Suppl 2):S786-90. PMC: 4606712. DOI: 10.4103/0975-7406.163563. View

16.

Kamma J, Vasdekis V, Romanos G . The effect of diode laser (980 nm) treatment on aggressive periodontitis: evaluation of microbial and clinical parameters. Photomed Laser Surg. 2009; 27(1):11-9. DOI: 10.1089/pho.2007.2233. View

17.

Vidovic Juras D, Lukac J, Cekic-Arambasin A, Vidovic A, Canjuga I, Sikora M . Effects of low-level laser treatment on mouth dryness. Coll Antropol. 2010; 34(3):1039-43. View

18.

Fidelix T, Czapkowski A, Azjen S, Andriolo A, Neto P, Trevisani V . Low-level laser therapy for xerostomia in primary Sjögren's syndrome: a randomized trial. Clin Rheumatol. 2017; 37(3):729-736. DOI: 10.1007/s10067-017-3898-9. View