Range Adaptation in Schizophrenia: A One-year Longitudinal Study

Overview

Journal Schizophr Res Cogn

Specialty Psychology

Date 2023 Dec 20

PMID 38115992

Authors

Ling-Ling Wang

Jing-Bo Gong

Yi-Hang Huang

Shu-Hong Shi

Chao Yan

Hui-Xin Hu

Yi Wang

Simon S Y Lui

Kang Ju

Raymond C K Chan

Affiliations

Soon will be listed here.

Abstract

Range adaptation refers to the representation of a stimulus value based on its relative position in the range of pre-experienced values. Altered range adaptation in value representation may be related to motivation and pleasure (MAP) deficit in schizophrenia (SCZ). This follow-up study examined the relationship between range adaptation performance and MAP symptoms in SCZ patients. We recruited 26 schizophrenia patients and followed them for 1 year. They completed an experimental task for estimating their range adaptation to outcome value (OV) and expected value (EV) at baseline and after 1 year. At baseline, we found a marginally significant and negative correlation between OV adaptation and avolition symptoms in SCZ patients. Moreover, the 1-year change of EV adaptation was significantly and negatively correlated with the change of self-report pleasure experience. Our results suggest that range adaptation may track the variations of MAP symptoms in SCZ.

References

Mallett R, Leff J, Bhugra D, Pang D, Zhao J . Social environment, ethnicity and schizophrenia. A case-control study. Soc Psychiatry Psychiatr Epidemiol. 2002; 37(7):329-35. DOI: 10.1007/s00127-002-0557-4. View

Wang L, Lam C, Huang J, Cheung E, Lui S, Chan R . Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study. Schizophr Bull. 2021; 47(6):1524-1533. PMC: 8530390. DOI: 10.1093/schbul/sbab099. View

Kobayashi S, Pinto de Carvalho O, Schultz W . Adaptation of reward sensitivity in orbitofrontal neurons. J Neurosci. 2010; 30(2):534-44. PMC: 2880492. DOI: 10.1523/JNEUROSCI.4009-09.2010. View

Andreasen N . The Scale for the Assessment of Negative Symptoms (SANS): conceptual and theoretical foundations. Br J Psychiatry Suppl. 1989; (7):49-58. View

Kirschner M, Hager O, Bischof M, Hartmann-Riemer M, Kluge A, Seifritz E . Deficits in context-dependent adaptive coding of reward in schizophrenia. NPJ Schizophr. 2016; 2:16020. PMC: 4945098. DOI: 10.1038/npjschz.2016.20. View

Kirschner M, Haugg A, Manoliu A, Simon J, Huys Q, Seifritz E . Deficits in context-dependent adaptive coding in early psychosis and healthy individuals with schizotypal personality traits. Brain. 2018; 141(9):2806-2819. DOI: 10.1093/brain/awy203. View

Barch D, Pagliaccio D, Luking K . Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia. Curr Top Behav Neurosci. 2015; 27:411-49. DOI: 10.1007/7854_2015_376. View

Kirkpatrick B, Strauss G, Nguyen L, Fischer B, Daniel D, Cienfuegos A . The brief negative symptom scale: psychometric properties. Schizophr Bull. 2010; 37(2):300-5. PMC: 3044634. DOI: 10.1093/schbul/sbq059. View

Kay S, Fiszbein A, Opler L . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987; 13(2):261-76. DOI: 10.1093/schbul/13.2.261. View

10.

Strauss G, Zamani Esfahlani F, Kirkpatrick B, Allen D, Gold J, Visser K . Network Analysis Reveals Which Negative Symptom Domains Are Most Central in Schizophrenia vs Bipolar Disorder. Schizophr Bull. 2019; 45(6):1319-1330. PMC: 6811832. DOI: 10.1093/schbul/sby168. View

11.

Kring A, Gur R, Blanchard J, Horan W, Reise S . The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation. Am J Psychiatry. 2013; 170(2):165-72. PMC: 3785242. DOI: 10.1176/appi.ajp.2012.12010109. View

12.

Berridge K, Kringelbach M . Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology (Berl). 2008; 199(3):457-80. PMC: 3004012. DOI: 10.1007/s00213-008-1099-6. View

13.

Rangel A, Clithero J . Value normalization in decision making: theory and evidence. Curr Opin Neurobiol. 2012; 22(6):970-81. PMC: 4334383. DOI: 10.1016/j.conb.2012.07.011. View

14.

Kaliuzhna M, Kirschner M, Tobler P, Kaiser S . Comparing adaptive coding of reward in bipolar I disorder and schizophrenia. Hum Brain Mapp. 2022; 44(2):523-534. PMC: 9842918. DOI: 10.1002/hbm.26078. View

15.

Chan R, Shi Y, Lai M, Wang Y, Wang Y, Kring A . The Temporal Experience of Pleasure Scale (TEPS): exploration and confirmation of factor structure in a healthy Chinese sample. PLoS One. 2012; 7(4):e35352. PMC: 3329425. DOI: 10.1371/journal.pone.0035352. View

16.

Pool E, Sennwald V, Delplanque S, Brosch T, Sander D . Measuring wanting and liking from animals to humans: A systematic review. Neurosci Biobehav Rev. 2016; 63:124-42. DOI: 10.1016/j.neubiorev.2016.01.006. View