Pediatric Primary Cutaneous Anaplastic Large-cell Lymphoma with Associated Hypovitaminosis D

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 2023 Dec 18

PMID 38108932

Authors

Eleanor Tung-Hahn

Valerie Mogilevskiy

Ellie Black

Michael Morgan

Rebecca Tung

Affiliations

Soon will be listed here.

Abstract

CD30+ lymphoproliferative diseases (LPDs) are relatively uncommon in the general population, especially in children. Distinguishing between the two main CD30+ LPDs, lymphomatoid papulosis and cutaneous anaplastic large-cell lymphoma is crucial, as the latter requires different treatment and systemic malignancy workup. We outline an uncommon presentation of a primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) accompanied by hypovitaminosis D in a young Hispanic child and a holistic approach to treatment. While baseline testing of vitamin D levels in patients with cutaneous lymphoma and LPDs is not yet the standard in dermatology, it is being increasingly performed by other specialties who care for solid tumor and hematologic malignancies, since low levels can portend poorer prognosis and outcomes. Although there are no precise treatment guidelines for pediatric PC-ALCL located in cosmetically sensitive areas, a minimally invasive therapeutic program comprised of shave removal, topical steroids, and correction of a potentially disease modifying comorbidity (hypovitaminosis D if present) offers a comprehensive approach.

Citing Articles

Vitamin D in Cutaneous T-Cell Lymphoma.

Odum A, Geisler C Cells. 2024; 13(6.

PMID: 38534347 PMC: 10969440. DOI: 10.3390/cells13060503.

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