Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease

Overview

Journal J Alzheimers Dis

Publisher Sage Publications

Specialties Geriatrics
Neurology

Date 2023 Dec 18

PMID 38108347

Authors

Svetlana Ukraintseva

Hongzhe Duan

Rachel Holmes

Olivia Bagley

Deqing Wu

Arseniy Yashkin

Alexander Kulminski

Igor Akushevich

Heather Whitson

Eric Stallard

Anatoliy Yashin

Konstantin Arbeev

Affiliations

Soon will be listed here.

Abstract

Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.

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References

Astell-Burt T, Navakatikyan M, Feng X . Behavioural change, weight loss and risk of dementia: A longitudinal study. Prev Med. 2020; 145:106386. DOI: 10.1016/j.ypmed.2020.106386. View

Backman K, Joas E, Waern M, Ostling S, Guo X, Blennow K . 37 Years of Body Mass Index and Dementia: Effect Modification by the APOE Genotype: Observations from the Prospective Population Study of Women in Gothenburg, Sweden. J Alzheimers Dis. 2015; 48(4):1119-27. DOI: 10.3233/JAD-150326. View

Blautzik J, Kotz S, Brendel M, Sauerbeck J, Vettermann F, Winter Y . Relationship Between Body Mass Index, ApoE4 Status, and PET-Based Amyloid and Neurodegeneration Markers in Amyloid-Positive Subjects with Normal Cognition or Mild Cognitive Impairment. J Alzheimers Dis. 2017; 65(3):781-791. DOI: 10.3233/JAD-170064. View

Bell S, Liu D, Samuels L, Shah A, Gifford K, Hohman T . Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia. J Nutr Health Aging. 2017; 21(10):1259-1267. PMC: 5736008. DOI: 10.1007/s12603-017-0906-3. View

Brinton R, Yao J, Yin F, Mack W, Cadenas E . Perimenopause as a neurological transition state. Nat Rev Endocrinol. 2015; 11(7):393-405. PMC: 9934205. DOI: 10.1038/nrendo.2015.82. View

Singh-Manoux A, Dugravot A, Shipley M, Brunner E, Elbaz A, Sabia S . Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement. 2017; 14(2):178-186. PMC: 5805839. DOI: 10.1016/j.jalz.2017.06.2637. View

Kang S, Kim Y, Jang W, Son K, Park H, Kim Y . Body mass index trajectories and the risk for Alzheimer's disease among older adults. Sci Rep. 2021; 11(1):3087. PMC: 7862316. DOI: 10.1038/s41598-021-82593-7. View

Li J, Liu C, Ang T, Au R . BMI decline patterns and relation to dementia risk across four decades of follow-up in the Framingham Study. Alzheimers Dement. 2022; 19(6):2520-2527. DOI: 10.1002/alz.12839. View

Seshadri S, Beiser A, Au R, Wolf P, Evans D, Wilson R . Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011; 7(1):35-52. PMC: 3039838. DOI: 10.1016/j.jalz.2010.12.002. View

10.

Kivimaki M, Luukkonen R, Batty G, Ferrie J, Pentti J, Nyberg S . Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals. Alzheimers Dement. 2017; 14(5):601-609. PMC: 5948099. DOI: 10.1016/j.jalz.2017.09.016. View

11.

Kulminski A, Loika Y, Culminskaya I, Huang J, Arbeev K, Bagley O . Independent associations of TOMM40 and APOE variants with body mass index. Aging Cell. 2018; 18(1):e12869. PMC: 6351823. DOI: 10.1111/acel.12869. View

12.

Leparulo A, Bisio M, Redolfi N, Pozzan T, Vassanelli S, Fasolato C . Accelerated Aging Characterizes the Early Stage of Alzheimer's Disease. Cells. 2022; 11(2). PMC: 8774248. DOI: 10.3390/cells11020238. View

13.

Crow R, Petersen C, Cook S, Stevens C, Titus A, Mackenzie T . Reported Weight Change in Older Adults and Presence of Frailty. J Frailty Aging. 2020; 9(2):74-81. PMC: 7202674. DOI: 10.14283/jfa.2019.44. View

14.

Lee C, Woodward M, Batty G, Beiser A, Bell S, Berr C . Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Obes Rev. 2020; 21(4):e12989. PMC: 7079047. DOI: 10.1111/obr.12989. View

15.

Alosco M, Duskin J, Besser L, Martin B, Chaisson C, Gunstad J . Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis. 2017; 57(3):953-968. PMC: 5526463. DOI: 10.3233/JAD-161205. View

16.

Rajan K, Skarupski K, Rasmussen H, Evans D . Gene-environment interaction of body mass index and apolipoprotein E ε4 allele on cognitive decline. Alzheimer Dis Assoc Disord. 2013; 28(2):134-40. PMC: 4002654. DOI: 10.1097/WAD.0000000000000013. View

17.

Wang C, Fu W, Cao S, Jiang H, Guo Y, Xv H . Weight Loss and the Risk of Dementia: A Meta-analysis of Cohort Studies. Curr Alzheimer Res. 2021; 18(2):125-135. DOI: 10.2174/1567205018666210414112723. View

18.

Ukraintseva S, Arbeev K, Duan M, Akushevich I, Kulminski A, Stallard E . Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity. Mech Ageing Dev. 2020; 194:111418. PMC: 7882032. DOI: 10.1016/j.mad.2020.111418. View

19.

Besser L, Gill D, Monsell S, Brenowitz W, Meranus D, Kukull W . Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord. 2013; 28(1):36-43. PMC: 3945175. DOI: 10.1097/WAD.0000000000000005. View

20.

Bachman D, Wolf P, Linn R, Knoefel J, Cobb J, Belanger A . Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology. 1992; 42(1):115-9. DOI: 10.1212/wnl.42.1.115. View