Osteoporosis in Rheumatology

Overview

Journal Indian J Orthop

Publisher Springer Nature

Specialty Orthopedics

Date 2023 Dec 18

PMID 38107813

Authors

S Chandrashekara

Affiliations

Soon will be listed here.

Abstract

Introduction: Osteoporosis is a common diagnosis and comorbidity observed in patients with rheumatic diseases. It is frequently associated with conditions such as rheumatoid arthritis, spondyloarthropathy, systemic lupus erythematosus, and other autoimmune rheumatic diseases.

Conclusion: The incidence of osteoporosis is influenced by factors such as uncontrolled disease, prolonged and higher doses of steroid use, immobility, advanced age, and postmenopausal status. Achieving good control of the underlying disease, minimizing or avoiding the use of steroids for extended periods, and ensuring adequate supplementation of vitamin D and calcium are crucial in reducing the incidence of osteoporosis. Regular screening and appropriate management of osteoporosis can significantly decrease the associated morbidity and mortality.

Citing Articles

Elucidating the role of FBXW4 in osteoporosis: integrating bioinformatics and machine learning for advanced insight.

Li J, Li J, Zheng M, Liu J, Zhao X BMC Pharmacol Toxicol. 2025; 26(1):20.

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From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases.

Gilcrease W, Manfredi L, Sciascia S, Ricceri F Rheumatol Ther. 2024; 12(1):1-24.

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References

Kareem R, Botleroo R, Bhandari R, Ogeyingbo O, Ahmed R, Gyawali M . The Impact of Rheumatoid Arthritis on Bone Loss: Links to Osteoporosis and Osteopenia. Cureus. 2021; 13(8):e17519. PMC: 8476196. DOI: 10.7759/cureus.17519. View

Sun Y, Feng X, He L, Zeng L, Hao Z, Lv X . Prevalence and possible risk factors of low bone mineral density in untreated female patients with systemic lupus erythematosus. Biomed Res Int. 2015; 2015:510514. PMC: 4337055. DOI: 10.1155/2015/510514. View

. Abstracts of the 9th International Congress on SLE. June 24-27 2010. Vancouver, Canada. Lupus. 2010; 19 Suppl 1:1-185. DOI: 10.1177/09612033100190010101. View

Sawicki P, Talalaj M, Zycinska K, Zgliczynski W, Wierzba W . Comparison of the Characteristics of Back Pain in Women with Postmenopausal Osteoporosis with and without Vertebral Compression Fracture: A Retrospective Study at a Single Osteoporosis Center in Poland. Med Sci Monit. 2021; 27:e929853. PMC: 7901154. DOI: 10.12659/MSM.929853. View

Mattia C, Coluzzi F, Celidonio L, Vellucci R . Bone pain mechanism in osteoporosis: a narrative review. Clin Cases Miner Bone Metab. 2016; 13(2):97-100. PMC: 5119722. DOI: 10.11138/ccmbm/2016.13.2.097. View

Mok C, Li O, Chan K, Ho L, Hui P . Effect of golimumab and pamidronate on clinical efficacy and MRI inflammation in axial spondyloarthritis: a 48-week open randomized trial. Scand J Rheumatol. 2015; 44(6):480-6. DOI: 10.3109/03009742.2015.1038300. View

Dougados M, Baeten D . Spondyloarthritis. Lancet. 2011; 377(9783):2127-37. DOI: 10.1016/S0140-6736(11)60071-8. View

Fitzgerald G, ODwyer T, Mockler D, OShea F, Wilson F . Pharmacological treatment for managing bone health in axial spondyloarthropathy: systematic review and meta-analysis. Rheumatol Int. 2020; 40(9):1369-1384. DOI: 10.1007/s00296-020-04623-3. View

Viapiana O, Gatti D, Idolazzi L, Fracassi E, Adami S, Troplini S . Bisphosphonates vs infliximab in ankylosing spondylitis treatment. Rheumatology (Oxford). 2013; 53(1):90-4. DOI: 10.1093/rheumatology/ket321. View

10.

Fitzgerald G, OShea F . The Fascinating Paradox of Osteoporosis in Axial Spondyloarthropathy. J Rheumatol. 2017; 44(12):1767-1776. DOI: 10.3899/jrheum.170051. View

11.

Hinze A, Louie G . Osteoporosis Management in Ankylosing Spondylitis. Curr Treatm Opt Rheumatol. 2017; 2(4):271-282. PMC: 5467452. DOI: 10.1007/s40674-016-0055-6. View

12.

Adami G, Fassio A, Rossini M, Caimmi C, Giollo A, Orsolini G . Osteoporosis in Rheumatic Diseases. Int J Mol Sci. 2019; 20(23). PMC: 6928928. DOI: 10.3390/ijms20235867. View

13.

Shankar S, Handa R, Aneja R, Marwaha V, Ammini A, Aprajita V . Bone mineral density in Indian women with rheumatoid arthritis. Rheumatol Int. 2008; 29(4):377-81. DOI: 10.1007/s00296-008-0706-5. View

14.

Klingberg E, Lorentzon M, Mellstrom D, Geijer M, Gothlin J, Hilme E . Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment. Arthritis Res Ther. 2012; 14(3):R108. PMC: 3446485. DOI: 10.1186/ar3833. View

15.

McQueenie R, Nicholl B, Jani B, Canning J, Macdonald S, McCowan C . Patterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis: a study of 5658 UK Biobank participants. BMJ Open. 2020; 10(11):e038829. PMC: 7684828. DOI: 10.1136/bmjopen-2020-038829. View

16.

van der Weijden M, Claushuis T, Nazari T, Lems W, Dijkmans B, van der Horst-Bruinsma I . High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review. Clin Rheumatol. 2012; 31(11):1529-35. PMC: 3483100. DOI: 10.1007/s10067-012-2018-0. View

17.

Dombestein Elde K, Madsen O . FRAX 10-yr Fracture Risk in Rheumatoid Arthritis-Assessments With and Without Bone Mineral Density May Lead to Very Different Results in the Individual Patient. J Clin Densitom. 2018; 22(1):31-38. DOI: 10.1016/j.jocd.2018.10.007. View

18.

. Diagnosis of osteoporosis in men, premenopausal women, and children. J Clin Densitom. 2004; 7(1):17-26. DOI: 10.1385/jcd:7:1:17. View

19.

Lim M, Kang K . A Contemporary View of the Diagnosis of Osteoporosis in Patients With Axial Spondyloarthritis. Front Med (Lausanne). 2020; 7:569449. PMC: 7759657. DOI: 10.3389/fmed.2020.569449. View