Unmasking Critical Illness: Using Machine Learning and Biomarkers to See What Lies Beneath

Overview

Journal Pediatr Crit Care Med

Specialty Pediatrics

Date 2023 Dec 18

PMID 38107599

Authors

Daniel Balcarcel

Julie C Fitzgerald

Alicia M Alcamo

Affiliations

Soon will be listed here.

References

Maslove D, Tang B, Shankar-Hari M, Lawler P, Angus D, Baillie J . Redefining critical illness. Nat Med. 2022; 28(6):1141-1148. DOI: 10.1038/s41591-022-01843-x. View

Knox D, Lanspa M, Kuttler K, Brewer S, Brown S . Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med. 2015; 41(5):814-22. PMC: 4607311. DOI: 10.1007/s00134-015-3764-7. View

Sinha P, Furfaro D, Cummings M, Abrams D, Delucchi K, Maddali M . Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids. Am J Respir Crit Care Med. 2021; 204(11):1274-1285. PMC: 8786071. DOI: 10.1164/rccm.202105-1302OC. View

Calfee C, Delucchi K, Parsons P, Thompson B, Ware L, Matthay M . Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med. 2014; 2(8):611-20. PMC: 4154544. DOI: 10.1016/S2213-2600(14)70097-9. View

Reddy K, Calfee C, McAuley D . Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits?. Am J Respir Crit Care Med. 2021; 203(12):1449-1451. PMC: 8483225. DOI: 10.1164/rccm.202101-0218ED. View

Seymour C, Kennedy J, Wang S, Chang C, Elliott C, Xu Z . Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. JAMA. 2019; 321(20):2003-2017. PMC: 6537818. DOI: 10.1001/jama.2019.5791. View

Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J . Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock. Pediatr Crit Care Med. 2023; 24(10):795-806. PMC: 10540758. DOI: 10.1097/PCC.0000000000003292. View

Carcillo J, Kernan K, Horvat C, Simon D, Aneja R . Why and How Is Hyperferritinemic Sepsis Different From Sepsis Without Hyperferritinemia?. Pediatr Crit Care Med. 2020; 21(5):509-512. PMC: 8121152. DOI: 10.1097/PCC.0000000000002285. View

Horvat C, Fabio A, Nagin D, Banks R, Qin Y, Park H . Mortality Risk in Pediatric Sepsis Based on C-reactive Protein and Ferritin Levels. Pediatr Crit Care Med. 2022; 23(12):968-979. PMC: 9722561. DOI: 10.1097/PCC.0000000000003074. View

10.

Dahmer M, Yang G, Zhang M, Quasney M, Sapru A, Weeks H . Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis. Lancet Respir Med. 2021; 10(3):289-297. PMC: 8897230. DOI: 10.1016/S2213-2600(21)00382-9. View