Applications of Cold Atmospheric Plasma in Immune-mediated Inflammatory Diseases Via Redox Homeostasis: Evidence and Prospects

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Dec 18

PMID 38107323

Authors

Yuyi Ma

Tuanhe Sun

Kaijie Ren

Tianhao Min

Xin Xie

Haonan Wang

Guimin Xu

Chengxue Dang

Hao Zhang

Affiliations

Soon will be listed here.

Abstract

As a representative technology in plasma medicine, cold atmospheric plasma (CAP) has beneficial outcomes in surface disinfection, wound repair, tissue regeneration, solid tumor therapy. Impact on immune response and inflammatory conditions was also observed in the process of CAP treatment. Relevant literatures were collected to assess efficacy and summarize possible mechanisms of the innovation. CAP mediates alteration in local immune microenvironment mainly through two ways. One is to down-regulate the expression level of several cytokines, impeding further conduction of immune or inflammatory signals. Intervening the functional phenotype of cells through different degree of oxidative stress is the other approach to manage the immune-mediated inflammatory disorders. A series of preclinical and clinical studies confirmed the therapeutic effect and side effects free of CAP. Moreover, several suggestions proposed in this manuscript might help to find directions for future investigation.

Citing Articles

[Mechanism of cold atmospheric plasma in treatment of chronic skin ulcer].

Yuan N, Yang Y, Tan C, Ran X Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024; 38(10):1283-1288.

PMID: 39433505 PMC: 11522536. DOI: 10.7507/1002-1892.202404027.

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