Nanopore Single-molecule Analysis of Biomarkers: Providing Possible Clues to Disease Diagnosis

Overview

Journal Trends Analyt Chem

Specialty Chemistry

Date 2023 Dec 18

PMID 38106545

Authors

Xiaohan Chen

Shuo Zhou

Yunjiao Wang

Ling Zheng

Sarah Guan

Deqiang Wang

Liang Wang

Xiyun Guan

Affiliations

Soon will be listed here.

Abstract

Biomarker detection has attracted increasing interest in recent years due to the minimally or non-invasive sampling process. Single entity analysis of biomarkers is expected to provide real-time and accurate biological information for early disease diagnosis and prognosis, which is critical to the effective disease treatment and is also important in personalized medicine. As an innovative single entity analysis method, nanopore sensing is a pioneering single-molecule detection technique that is widely used in analytical bioanalytical fields. In this review, we overview the recent progress of nanopore biomarker detection as new approaches to disease diagnosis. In highlighted studies, nanopore was focusing on detecting biomarkers of different categories of communicable and noncommunicable diseases, such as pandemic Covid-19, AIDS, cancers, neurologic diseases, etc. Various sensitive and selective nanopore detecting strategies for different types of biomarkers are summarized. In addition, the challenges, opportunities, and direction for future development of nanopore-based biomarker sensors are also discussed.

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