Factors Affecting the Early Establishment of Neonatal Intestinal Flora and Its Intervention Measures

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2023 Dec 18

PMID 38106467

Authors

Guangyu Ma

Yuguo Shi

Lulu Meng

Haolong Fan

Xiaomei Tang

Huijuan Luo

Dongju Wang

Juan Zhou

Xiaomin Xiao

Affiliations

Soon will be listed here.

Abstract

In recent years, it has become evident that early-life intestinal flora plays a pivotal role in determining human health. Consequently, it is imperative to explore the establishment of neonatal intestinal flora and its influencing factors. Early neonatal intestinal flora is influenced by a multitude of factors, including maternal and infant-related factors, as well as external environment. This review summarizes the colonization mechanism of intestinal flora in the early life of newborns and discussed their influence on the establishment of neonatal intestinal flora, taking into account factors such as delivery mode, gestational age and feeding mode. Additionally, this review delves into the natural or artificial reconstruction of intestinal flora colonization defects in infants born via cesarean section and premature infants, with the goal of establishing a theoretical foundation for preventing and treating issues related to neonatal intestinal flora colonization and associated diseases.

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