OFFSPRING: A SPRING Follow-Up Study Assessing the Efficacy of Maternal Probiotics and Allergic Disease in the Child

Overview

Journal Int Arch Allergy Immunol

Specialty Allergy & Immunology

Date 2023 Dec 17

PMID 38104554

Authors

Emma V Shipton

Katie Foxcroft

Marloes Dekker Nitert

H David McIntyre

Helen Barrett

Mimi Tang

Leonie Callaway

Affiliations

Soon will be listed here.

Abstract

Introduction: There are a variety of factors that contribute to the development of allergic diseases in children, including environmental exposures during the maternal prenatal period. It has been proposed that probiotic supplementation during pregnancy could be used as a possible preventative measure to target childhood allergic disease.

Methods: Participants from a previously conducted prospective double-blind randomised control trial of probiotics versus placebo study (Study of PRrobiotics IN Gestation) were sent electronic questionnaires to complete about their child, who are now between 3 and 7 years of age. Demographic data and rates of allergic diseases were compared between the two groups.

Results: One hundred and seven women responded to the questionnaires. Between the two groups, there was no difference in the frequency of allergic diseases, with similar rates of eczema, asthma, and hospital presentations seen.

Conclusion: In this follow-up study, infants of mothers who were exposed to probiotics during their pregnancy do not appear to have any paediatric health advantages in terms of allergic diseases.

Citing Articles

The Link Between Dysbiosis, Inflammation, Oxidative Stress, and Asthma-The Role of Probiotics, Prebiotics, and Antioxidants.

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Can probiotics be used in the prevention and treatment of bronchial asthma?.

Kleniewska P, Pawliczak R Pharmacol Rep. 2024; 76(4):740-753.

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