Enhancing Sensitivity of Triple-negative Breast Cancer to DNA-damaging Therapy Through Chemical Inhibition of the M6A Methyltransferase METTL3

Overview

Journal Cancer Commun (Lond)

Publisher Wiley

Specialty Oncology

Date 2023 Dec 16

PMID 38102821

Authors

Bianca Cesaro

Alessia Iaiza

Fabio Piscopo

Marco Tarullo

Eleonora Cesari

Dante Rotili

Antonello Mai

Alberto Diana

Michela Londero

Luca Del Giacco

Riccardo Masetti

Alba Di Leone

Chiara Naro

Silvia Masciarelli

Giulia Fontemaggi

Claudio Sette

Francesco Fazi

Alessandro Fatica

Affiliations

Soon will be listed here.

Citing Articles

The role of N(6)-methyladenosine (m6a) modification in cancer: recent advances and future directions.

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Triple-Negative Breast Cancer Progression and Drug Resistance in the Context of Epithelial-Mesenchymal Transition.

Blaszczak E, Miziak P, Odrzywolski A, Baran M, Gumbarewicz E, Stepulak A Cancers (Basel). 2025; 17(2).

PMID: 39858010 PMC: 11764116. DOI: 10.3390/cancers17020228.

The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD.

Shuai Y, Ma Z, Ju J, Li C, Bai X, Yue J Apoptosis. 2024; 30(1-2):226-238.

PMID: 39627574 DOI: 10.1007/s10495-024-02037-1.

METTL Family in Healthy and Disease.

He J, Hao F, Song S, Zhang J, Zhou H, Zhang J Mol Biomed. 2024; 5(1):33.

PMID: 39155349 PMC: 11330956. DOI: 10.1186/s43556-024-00194-y.

N-methyladenosine (mA) RNA modification in chronic myeloid leukemia: unveiling a novel therapeutic target.

Fernandez Rodriguez G, Tarullo M, Fatica A Cell Mol Life Sci. 2024; 81(1):326.

PMID: 39085650 PMC: 11335252. DOI: 10.1007/s00018-024-05379-w.

References

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Ye F, Dewanjee S, Li Y, Jha N, Chen Z, Kumar A . Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer. Mol Cancer. 2023; 22(1):105. PMC: 10324146. DOI: 10.1186/s12943-023-01805-y. View

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