Correlation of Contrast Sensitivity with Ganglion Cell/inner Plexiform Layer Thickness and Damage Location in Glaucoma with Varying Severity

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2023 Dec 15

PMID 38102474

Authors

Ruiqi Pang

Jieting Peng

Qing Zhang

Kai Cao

Zhong-Lin Lu

Ningli Wang

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the correlation of contrast sensitivity with macular region ganglion cell/inner plexiform layer (GC/IPL) thickness and damage location in open-angle glaucoma (OAG) of varying severity.

Methods: Cross-sectional study with 106 patients (203 eyes) who had OAG. Contrast sensitivity of each eye evaluated by quick contrast sensitivity function test based on intelligent algorithm. The GC/IPL thickness measured with optical coherence tomography; six sectors were delineated for localization of damage area. All eyes were grouped by the healthy macular sector and divided into pre-perimetric, early, moderate, and advanced stages, according to severity of visual field impairment.

Results: Mean GC/IPL thickness in the entire macular region and each sector were correlated with parameters that reflected contrast sensitivity (p < 0.01). The structure-function correlations were stronger nasally compared with temporally, and superiorly compared with inferiorly. Eyes with normal structure in inferior temporal sector had less visual field (p' = 0.024) and macular damage (p' = 0.034) compared with eyes that had healthy superior nasal sector; there was no difference in contrast sensitivity (p = 0.898). The structure-function correlations were significant in early, moderate, and advanced glaucoma (p < 0.05) but not in pre-perimetric glaucoma (p = 0.116).

Conclusions: GC/IPL thinning in all sectors of the macular region in OAG was correlated with contrast sensitivity impairment, whereas the inferior temporal sector was least affected. Contrast sensitivity was supported as a severity evaluation indicator of early, moderate, and advanced glaucoma, but not of pre-perimetric glaucoma.

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