Considering Molecular Alterations As Pan-cancer Tissue-agnostic Targets
Overview
Affiliations
Tumour-agnostic kinase inhibitors.
Adashek J, Nikanjam M, Kurzrock R Nat Rev Drug Discov. 2025; .
PMID: 40050521 DOI: 10.1038/s41573-025-01147-y.
Adashek J, Munoz J, Kurzrock R Med. 2024; 6(1):100550.
PMID: 39689708 PMC: 11725447. DOI: 10.1016/j.medj.2024.11.003.
Lazar V, Raymond E, Magidi S, Bresson C, Wunder F, Berindan-Neagoe I Ther Adv Med Oncol. 2024; 16:17588359241289200.
PMID: 39429467 PMC: 11487509. DOI: 10.1177/17588359241289200.
If it's a target, it's a pan-cancer target: Tissue is not the issue.
Adashek J, Kato S, Sicklick J, Lippman S, Kurzrock R Cancer Treat Rev. 2024; 125:102721.
PMID: 38522181 PMC: 11093268. DOI: 10.1016/j.ctrv.2024.102721.
Forget lung, breast or prostate cancer: why tumour naming needs to change.
Andre F, Rassy E, Marabelle A, Michiels S, Besse B Nature. 2024; 626(7997):26-29.
PMID: 38347121 DOI: 10.1038/d41586-024-00216-3.