The Use of Calprotectin and Other Inflammatory Parameters in the Investigation of Pseudoexfoliation Syndrome Concomitant Glaucoma and Systemic Diseases

Overview

Journal Indian J Ophthalmol

Specialty Ophthalmology

Date 2023 Dec 15

PMID 38099372

Authors

Erdogan Yasar

Huseyin Erdal

Sibel Cigdem Tuncer

Betul Akbulut Yagci

Affiliations

Soon will be listed here.

Abstract

Purpose: The present study aimed to investigate the value of calprotectin and other inflammatory parameters in patients with glaucoma and systemic diseases accompanying pseudoexfoliation syndrome (PEX-S).

Methods: This prospective study included 45 PEX-S patients and 45 non-PEX control patients. Patients were investigated for the presence of glaucoma, cardiovascular disease (CVD), ischemic brain disease (IBD), Alzheimer's disease, and neurosensory hearing loss (NSHL). After excluding diseases that may affect inflammatory parameters, a detailed biomicroscopic examination, and blood tests were performed for the patients.

Results: Glaucoma, CVD, NVK, Alzheimer's disease, and NSHL were high in the PEX-S group ( P = 0.01, P = 0.01, P = 0.04, P = 0.04, and P = 0.03, respectively). Calprotectin, ferritin, neutrophil-to-platelet ratio, and lymphocyte-to-platelet ratio were found to be high in the PEX-S group ( P < 0.01, P = 0.04, P < 0.01, and P < 0.01, respectively). On evaluating the relationship between PEX-S and glaucoma and systemic diseases, it was found that elevated calprotectin increased the risk of glaucoma by 4.36 times and elevated neutrophil-to-lymphocyte ratio (NLR) increased the risk of CVD by 3.23 times in PEX-S patients ( P = 0.02 and P = 0.03, respectively).

Conclusion: This study demonstrated the value of calprotectin elevation in detecting concomitant glaucoma in PEX-S patients and, in addition, the value of NLR elevation in detecting concomitant CVD.

References

Schlotzer-Schrehardt U, Lommatzsch J, Kuchle M, Konstas A, Naumann G . Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003; 44(3):1117-25. DOI: 10.1167/iovs.02-0365. View

Yildirim N, Yasar E, Gursoy H, Colak E . Prevalence of pseudoexfoliation syndrome and its association with ocular and systemic diseases in Eskisehir, Turkey. Int J Ophthalmol. 2017; 10(1):128-134. PMC: 5225361. DOI: 10.18240/ijo.2017.01.21. View

Candar T, Baklaci D, Kuzucu I, Kayabasi S . A proinflammatory marker in chronic rhinosinusitis: serum calprotectin. Acta Biochim Pol. 2020; 67(3):367-371. DOI: 10.18388/abp.2020_5204. View

Koca M, Naumann G, Volkholz H . Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder?. Arch Ophthalmol. 1992; 110(12):1752-6. DOI: 10.1001/archopht.1992.01080240092038. View

Mitchell P, Wang J, Smith W . Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol. 1997; 124(5):685-7. DOI: 10.1016/s0002-9394(14)70908-0. View

Ozkan D, Altan C, Er M, Gultekin F, Kuras S, Artunay O . The Role of Oxidative Status in the Pathogenesis of Primary Open-Angle Glaucoma, Pseudoexfolyation Syndrome and Glaucoma. Eur J Ophthalmol. 2022; 33(1):352-360. DOI: 10.1177/11206721221113199. View

Shabani F, Farasat A, Mahdavi M, Gheibi N . Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer. Inflamm Res. 2018; 67(10):801-812. DOI: 10.1007/s00011-018-1173-4. View

Melese E, Shibeshi M, Sherief S . Prevalence of Pseudoexfoliation Among Adults and Its Related Ophthalmic Variables in Southern Ethiopia: A Cross-Sectional Study. Clin Ophthalmol. 2022; 16:3951-3958. PMC: 9719280. DOI: 10.2147/OPTH.S391290. View

Zenkel M, Lewczuk P, Junemann A, Kruse F, Naumann G, Schlotzer-Schrehardt U . Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma. Am J Pathol. 2010; 176(6):2868-79. PMC: 2877848. DOI: 10.2353/ajpath.2010.090914. View

10.

Inciarte-Mundo J, Frade-Sosa B, Sanmarti R . From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis. Front Immunol. 2022; 13:1001025. PMC: 9672845. DOI: 10.3389/fimmu.2022.1001025. View

11.

Lin Y, Dai W, Chen Y, He X, Xu Y . Neutrophil-to-platelet ratio predicts mortality following percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction. Front Physiol. 2022; 13:1011048. PMC: 9527305. DOI: 10.3389/fphys.2022.1011048. View

12.

Li Y, Yang X, Zhou H, Hui X, Li H, Zheng J . A high neutrophil-to-platelet ratio is associated with hematoma expansion in patients with spontaneous intracerebral hemorrhage: a retrospective study. BMC Neurol. 2023; 23(1):27. PMC: 9847168. DOI: 10.1186/s12883-023-03055-3. View

13.

Topuz M, Binnetoglu A, Yumusakhuylu A, Sari M, Baglam T, Gerin F . Circulating calprotectin as a biomarker of laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2017; 274(6):2499-2504. DOI: 10.1007/s00405-017-4480-4. View

14.

Zeng J, Liu X, Liu J, Wu P, Yang L . Linkage of calprotectin with inflammation, activity and treatment response of rheumatoid arthritis: a meta-analysis. Biomark Med. 2023; 16(17):1239-1249. DOI: 10.2217/bmm-2022-0216. View

15.

Pang J, Liu J, Liang W, Yang L, Wu L . High Neutrophil-to-Platelet Ratio Is Associated with Poor Survival in Patients with Acute Aortic Dissection. Dis Markers. 2022; 2022:5402507. PMC: 9239768. DOI: 10.1155/2022/5402507. View

16.

Wang S, Miao S, Qiu X, Wu J, Wang Y . Fecal calprotectin in predicting small bowel capsule endoscopy findings in pediatric patients with known Crohn's disease. Medicine (Baltimore). 2022; 101(42):e31163. PMC: 9592269. DOI: 10.1097/MD.0000000000031163. View

17.

Yaz Y, Yildirim N, Aydin Yaz Y, Cilingir O, Yuksel Z, Mutlu F . Three Single Nucleotide Polymorphisms of ' in a Turkish Population with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Turk J Ophthalmol. 2018; 48(5):215-220. PMC: 6216538. DOI: 10.4274/tjo.83797. View

18.

Sarenac Vulovic T, Pavlovic S, Jakovljevic V, Janicijevic K, Zdravkovic N . Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma. Int J Ophthalmol. 2016; 9(8):1138-42. PMC: 4990578. DOI: 10.18240/ijo.2016.08.09. View

19.

Yildirim Z, Yildirim F, Ucgun N, Sepici-Dincel A . The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome. Int J Ophthalmol. 2013; 6(1):50-3. PMC: 3580249. DOI: 10.3980/j.issn.2222-3959.2013.01.10. View

20.

Abd El Meged Nage S, Esmail A . Calprotectin as a Biomarker for Diagnosis and Severity of Acute Noninfectious Anterior Uveitis in Egyptian Patients. Clin Ophthalmol. 2022; 16:4109-4120. PMC: 9759012. DOI: 10.2147/OPTH.S389780. View