Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent in Mice

Overview

Journal JACC Basic Transl Sci

Date 2023 Dec 14

PMID 38093743

Authors

Cecile Oury

Severien Meyers

Nicolas Jacques

Kirsten Leeten

Zheshen Jiang

Lucia Musumeci

Marleen Lox

Margaux Debuisson

Eric Goffin

Bernard Pirotte

Philippe Delvenne

Alain Nchimi

Cedric Hubert

Melanie Heptia

Philippe Hubert

Marijke J E Kuijpers

Thomas Vanassche

Kimberly Martinod

Peter Verhamme

Patrizio Lancellotti

Affiliations

Soon will be listed here.

Abstract

In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent . Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against . Ticagrelor antiplatelet activity further interferes with the interplay between platelets and bacteria.

Citing Articles

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