Systems Immunology Spanning Tumors, Lymph Nodes, and Periphery

Overview

Journal Cell Rep Methods

Specialty Cell Biology

Date 2023 Dec 12

PMID 38086385

Authors

Dimitrios N Sidiropoulos

Won Jin Ho

Elizabeth M Jaffee

Luciane T Kagohara

Elana J Fertig

Affiliations

Soon will be listed here.

Abstract

The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic interactions between immune and cancer cells contribute to disease progression. Lymphocytes are activated in lymph nodes, traffic through the periphery, and impact cancer progression through their interactions with tumor cells. As a result, therapeutic response and resistance are mediated across tissues, and a comprehensive understanding of lymphocyte dynamics requires a systems-level approach. In this review, we highlight experimental and computational methods that can leverage the study of leukocyte trafficking through an immunomics lens and reveal how adaptive immunity shapes cancer.

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References

Du W, Nair P, Johnston A, Wu P, Wirtz D . Cell Trafficking at the Intersection of the Tumor-Immune Compartments. Annu Rev Biomed Eng. 2022; 24:275-305. PMC: 9811395. DOI: 10.1146/annurev-bioeng-110320-110749. View

Racle J, de Jonge K, Baumgaertner P, Speiser D, Gfeller D . Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data. Elife. 2017; 6. PMC: 5718706. DOI: 10.7554/eLife.26476. View

Burkhardt D, Stanley 3rd J, Tong A, Perdigoto A, Gigante S, Herold K . Quantifying the effect of experimental perturbations at single-cell resolution. Nat Biotechnol. 2021; 39(5):619-629. PMC: 8122059. DOI: 10.1038/s41587-020-00803-5. View

Lin J, Fallahi-Sichani M, Chen J, Sorger P . Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging. Curr Protoc Chem Biol. 2016; 8(4):251-264. PMC: 5233430. DOI: 10.1002/cpch.14. View

Maas S, Breakefield X, Weaver A . Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends Cell Biol. 2016; 27(3):172-188. PMC: 5318253. DOI: 10.1016/j.tcb.2016.11.003. View

Jia Q, Chu H, Jin Z, Long H, Zhu B . High-throughput single-сell sequencing in cancer research. Signal Transduct Target Ther. 2022; 7(1):145. PMC: 9065032. DOI: 10.1038/s41392-022-00990-4. View

von Andrian U, Mempel T . Homing and cellular traffic in lymph nodes. Nat Rev Immunol. 2003; 3(11):867-78. DOI: 10.1038/nri1222. View

Ellingsen E, Bounova G, Kerzeli I, Anzar I, Simnica D, Aamdal E . Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination. J Transl Med. 2022; 20(1):419. PMC: 9465869. DOI: 10.1186/s12967-022-03624-z. View

Porciello N, Franzese O, DAmbrosio L, Palermo B, Nistico P . T-cell repertoire diversity: friend or foe for protective antitumor response?. J Exp Clin Cancer Res. 2022; 41(1):356. PMC: 9773533. DOI: 10.1186/s13046-022-02566-0. View

10.

Schwickert T, Lindquist R, Shakhar G, Livshits G, Skokos D, Kosco-Vilbois M . In vivo imaging of germinal centres reveals a dynamic open structure. Nature. 2007; 446(7131):83-7. DOI: 10.1038/nature05573. View

11.

Schreiber R, Old L, Smyth M . Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011; 331(6024):1565-70. DOI: 10.1126/science.1203486. View

12.

Park J, Kim J, Lewy T, Rice C, Elemento O, Rendeiro A . Spatial omics technologies at multimodal and single cell/subcellular level. Genome Biol. 2022; 23(1):256. PMC: 9746133. DOI: 10.1186/s13059-022-02824-6. View

13.

Aran D, Looney A, Liu L, Wu E, Fong V, Hsu A . Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019; 20(2):163-172. PMC: 6340744. DOI: 10.1038/s41590-018-0276-y. View

14.

Wherry E . T cell exhaustion. Nat Immunol. 2011; 12(6):492-9. DOI: 10.1038/ni.2035. View

15.

McGranahan N, Rosenthal R, Hiley C, Rowan A, Watkins T, Wilson G . Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Cell. 2017; 171(6):1259-1271.e11. PMC: 5720478. DOI: 10.1016/j.cell.2017.10.001. View

16.

Stein J, F Gonzalez S . Dynamic intravital imaging of cell-cell interactions in the lymph node. J Allergy Clin Immunol. 2017; 139(1):12-20. DOI: 10.1016/j.jaci.2016.11.008. View

17.

Alitalo K . The lymphatic vasculature in disease. Nat Med. 2011; 17(11):1371-80. DOI: 10.1038/nm.2545. View

18.

Subrahmanyam P, Dong Z, Gusenleitner D, Giobbie-Hurder A, Severgnini M, Zhou J . Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients. J Immunother Cancer. 2018; 6(1):18. PMC: 5840795. DOI: 10.1186/s40425-018-0328-8. View

19.

Reid J, Wernisch L . Pseudotime estimation: deconfounding single cell time series. Bioinformatics. 2016; 32(19):2973-80. PMC: 5039927. DOI: 10.1093/bioinformatics/btw372. View

20.

Hunter M, Teijeira A, Halin C . T Cell Trafficking through Lymphatic Vessels. Front Immunol. 2017; 7:613. PMC: 5174098. DOI: 10.3389/fimmu.2016.00613. View