Association Between Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2023 Dec 12

PMID 38084269

Authors

Miao Zeng

Yiping Liu

Yunquan Xie

Affiliations

Soon will be listed here.

Abstract

Background: Aldehyde dehydrogenase 2 () polymorphisms have been extensively studied in patients with hypertension (HTN) and diabetes mellitus (DM) in recent years. However, it is unclear whether polymorphisms are correlated with the risk of developing DM in patients with HTN. This study was designed to examine the association between single nucleotide polymorphism (SNP) rs671 and the risks of DM in patients with HTN.

Methods: This study retrospectively analyzed the patients with HTN who were treated in Meizhou People's Hospital from August 2016 to December 2020, 788 HTN patients with DM as case patients, and 1632 HTN patients without DM history as controls. polymorphisms were analyzed using a polymerase chain reaction (PCR)-gene chip. Differences in genotypes between subjects and controls were compared. To analyze the relationship between genotype and DM risk, multiple logistic regression analysis was performed after adjusting for gender, age, smoking history, and drinking history.

Results: The proportion of the G/A plus A/A genotype was significantly higher in patients with DM than in controls (52.8% vs 48.2%, =0.033). DM patients with G/A genotype had lower LDL-C (<0.017) than those with G/G genotype. The results of logistic regression analysis indicated that the G/A genotype increased the risk of DM in HTN patients, with an adjusted odds ratio (OR) of 1.209 (95% confidence interval (CI) 1.010-1.446) (=0.038), whereas the G/A plus A/A genotype in the dominant model increased the risk of DM significantly, with an adjusted OR of 1.203 (95% CI 1.013-1.428) (=0.035).

Conclusion: A allele (G/A + A/A genotype) increased the risk of DM in patients with HTN.

Citing Articles

The Applicability and Limitations of the Spectrofluorometric Method for Determination of ALDH1 Activity in Serum and Plasma.

Michorowska S, Wisniewska A, Wolinowska R, Wroczynski P, Giebultowicz J Diagnostics (Basel). 2024; 14(23).

PMID: 39682629 PMC: 11640014. DOI: 10.3390/diagnostics14232721.

ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation.

Paquay S, Duraffourd J, Bury M, Heremans I, Caligiore F, Gerin I Cell Mol Life Sci. 2024; 81(1):367.

PMID: 39174697 PMC: 11342911. DOI: 10.1007/s00018-024-05397-8.

Associations of ACE I/D and AGTR1 rs5182 polymorphisms with diabetes and their effects on lipids in an elderly Chinese population.

Liu J, Yi Y, Guo Q, Jia K, Li X, Cai J Lipids Health Dis. 2024; 23(1):231.

PMID: 39080710 PMC: 11290002. DOI: 10.1186/s12944-024-02222-w.

Investigation of the molecular mechanism of Roxb. in treating hypertension based on proteomics and bioinformatics.

Yang X, Qian H, Yang C, Zhang Z Front Pharmacol. 2024; 15:1360829.

PMID: 38783958 PMC: 11112092. DOI: 10.3389/fphar.2024.1360829.

References

He Z, Guo Q, Ling Y, Hong C, Liu Y, Jin X . Aldehyde dehydrogenase 2 rs671 polymorphism and multiple diseases: protocol for a quantitative umbrella review of meta-analyses. Syst Rev. 2022; 11(1):185. PMC: 9438126. DOI: 10.1186/s13643-022-02050-y. View

Koye D, Magliano D, Reid C, Pavkov M, Chadban S, McDonald S . Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013. Am J Kidney Dis. 2018; 73(3):300-308. DOI: 10.1053/j.ajkd.2018.10.005. View

Holst C, Becker U, Jorgensen M, Gronbaek M, Tolstrup J . Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population. Diabetologia. 2017; 60(10):1941-1950. DOI: 10.1007/s00125-017-4359-3. View

Zhang M, Zhou J, Liu Y, Sun X, Luo X, Han C . Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study. Diabetes Res Clin Pract. 2017; 135:150-157. DOI: 10.1016/j.diabres.2017.11.011. View

Zeng D, Huang Q, Yu Z, Wu H . Association between aldehyde dehydrogenase 2 gene rs671 G>A polymorphism and alcoholic liver cirrhosis in southern Chinese Hakka population. J Clin Lab Anal. 2021; 35(7):e23855. PMC: 8274999. DOI: 10.1002/jcla.23855. View

Yoshida A, Rzhetsky A, Hsu L, Chang C . Human aldehyde dehydrogenase gene family. Eur J Biochem. 1998; 251(3):549-57. DOI: 10.1046/j.1432-1327.1998.2510549.x. View

. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159):1736-1788. PMC: 6227606. DOI: 10.1016/S0140-6736(18)32203-7. View

Ma C, Yu B, Zhang W, Wang W, Zhang L, Zeng Q . Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people. Sci Rep. 2017; 7(1):11136. PMC: 5593832. DOI: 10.1038/s41598-017-11071-w. View

OShea P, Griffin T, Fitzgibbon M . Hypertension: The role of biochemistry in the diagnosis and management. Clin Chim Acta. 2016; 465:131-143. DOI: 10.1016/j.cca.2016.12.014. View

10.

Chen Y, Peng G, Tsao T, Wang M, Lu R, Yin S . Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics. 2009; 19(8):588-99. DOI: 10.1097/FPC.0b013e32832ecf2e. View

11.

Cheung B, Li C . Diabetes and hypertension: is there a common metabolic pathway?. Curr Atheroscler Rep. 2012; 14(2):160-6. PMC: 3314178. DOI: 10.1007/s11883-012-0227-2. View

12.

Li G, Li Z, Li F, Dong L, Tang L, Xiang J . Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy. Int J Environ Res Public Health. 2017; 14(2). PMC: 5334719. DOI: 10.3390/ijerph14020165. View

13.

Eugui J, Logrono M, Ruiz R, Zugaza C, Mirabel J, Martinez C . Immunoturbidimetry of serum apolipoproteins A-I and B on the Cobas Bio centrifugal analyzer: method validation and reference values. Clin Biochem. 1994; 27(4):310-5. DOI: 10.1016/0009-9120(94)90035-3. View

14.

Zhang M, Shi Y, Zhou B, Huang Z, Zhao Z, Li C . Prevalence, awareness, treatment, and control of hypertension in China, 2004-18: findings from six rounds of a national survey. BMJ. 2023; 380:e071952. PMC: 10498511. DOI: 10.1136/bmj-2022-071952. View

15.

Spracklen C, Horikoshi M, Kim Y, Lin K, Bragg F, Moon S . Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature. 2020; 582(7811):240-245. PMC: 7292783. DOI: 10.1038/s41586-020-2263-3. View

16.

Alloubani A, Saleh A, Abdelhafiz I . Hypertension and diabetes mellitus as a predictive risk factors for stroke. Diabetes Metab Syndr. 2018; 12(4):577-584. DOI: 10.1016/j.dsx.2018.03.009. View

17.

Bastawrous A, Mathenge W, Wing K, Bastawrous M, Rono H, Weiss H . The incidence of diabetes mellitus and diabetic retinopathy in a population-based cohort study of people age 50 years and over in Nakuru, Kenya. BMC Endocr Disord. 2017; 17(1):19. PMC: 5364612. DOI: 10.1186/s12902-017-0170-x. View

18.

Xu F, Chen Y, Lv R, Zhang H, Tian H, Bian Y . ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients. Hypertens Res. 2009; 33(1):49-55. DOI: 10.1038/hr.2009.178. View

19.

Li H, Hu Y, Lin H, Xia H, Guo Y, Wu F . Hypertension and Comorbidities in Rural and Urban Chinese Older People: An Epidemiological Subanalysis From the SAGE Study. Am J Hypertens. 2020; 34(2):183-189. DOI: 10.1093/ajh/hpaa146. View

20.

Muilwijk M, Bolijn R, Galenkamp H, Stronks K, van Charante E, van Valkengoed I . The association between gender-related characteristics and type 2 diabetes risk in a multi-ethnic population: The HELIUS study. Nutr Metab Cardiovasc Dis. 2021; 32(1):142-150. DOI: 10.1016/j.numecd.2021.09.015. View