Prediction of Post-stroke Depression with Combined Blood Biomarkers IL-6, TNF-a, and Fatty Acid Binding Protein: A Prospective Study

Overview

Journal J Med Biochem

Specialty Biochemistry

Date 2023 Dec 12

PMID 38084247

Authors

Linlin Wang

Chen Chunyou

Jingang Zhu

Xianjun Bao

Xiaoxiao Tao

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumour necrosis factor (TNF-a), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence.

Methods: Clinical data of stroke patients admitted to the First People's Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and nonPSD groups. The blood levels of IL-6, TNF-a, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed.

Results: The PSD group had significantly higher levels of IL-6, TNF-a, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker.

Conclusions: The study indicates that the levels of IL-6, TNF-a, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value.

Citing Articles

The association between triglyceride-glucose index and its combination with post-stroke depression: NHANES 2005-2018.

Liang F, Shan X, Chen X, Yang B BMC Psychiatry. 2025; 25(1):243.

PMID: 40087591 DOI: 10.1186/s12888-025-06676-9.

References

Coppack S . Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc. 2001; 60(3):349-56. DOI: 10.1079/pns2001110. View

Das J, G K R . Post stroke depression: The sequelae of cerebral stroke. Neurosci Biobehav Rev. 2018; 90:104-114. DOI: 10.1016/j.neubiorev.2018.04.005. View

Li R, Fan W, Li D, Liu X . Correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in acute ischemic stroke patients. Braz J Med Biol Res. 2022; 55:e11517. PMC: 8905669. DOI: 10.1590/1414-431X2021e11517. View

Carnac T . Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance. Front Syst Neurosci. 2022; 16:844383. PMC: 9283579. DOI: 10.3389/fnsys.2022.844383. View

Diaz D, Lopez-Dolado E, Haro S, Monserrat J, Martinez-Alonso C, Balomeros D . Systemic Inflammation and the Breakdown of Intestinal Homeostasis Are Key Events in Chronic Spinal Cord Injury Patients. Int J Mol Sci. 2021; 22(2). PMC: 7828526. DOI: 10.3390/ijms22020744. View

Wei M, Huang Q, Liu Z, Luo Y, Xia J . Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke. CNS Neurol Disord Drug Targets. 2021; 20(5):401-416. DOI: 10.2174/1871527320666210322115808. View

Irmak On B, Vidal X, Berger U, Sabate M, Ballarin E, Maisterra O . Antidepressant use and stroke or mortality risk in the elderly. Eur J Neurol. 2021; 29(2):469-477. DOI: 10.1111/ene.15137. View

Bake S, Hurst D, Miranda R, Sohrabji F . Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery from the effects of an adult-onset cerebrovascular ischemic stroke. Alcohol Clin Exp Res. 2022; 46(12):2267-2279. PMC: 10100487. DOI: 10.1111/acer.14952. View

Kwah L, Diong J . National Institutes of Health Stroke Scale (NIHSS). J Physiother. 2014; 60(1):61. DOI: 10.1016/j.jphys.2013.12.012. View

10.

Mu Y, Wang Z, Zhou J, Tan C, Wang H . Correlations of Post-stroke Depression with Inflammatory Response Factors. Iran J Public Health. 2018; 47(7):988-993. PMC: 6119581. View

11.

Wu H, Wang J, Teng T, Yin B, He Y, Jiang Y . Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder. J Affect Disord. 2022; 323:659-666. DOI: 10.1016/j.jad.2022.11.058. View

12.

El-Hakim Y, Mani K, Eldouh A, Pandey S, Grimaldo M, Dabney A . Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats. Biol Sex Differ. 2021; 12(1):14. PMC: 7811247. DOI: 10.1186/s13293-020-00352-1. View

13.

Li J, Zheng J, Jin X, Zhu K, Wang X, Zhang H . Intestinal barrier dysfunction is involved in the development of systemic inflammatory responses and lung injury in type A aortic dissection: a case-control study. J Thorac Dis. 2022; 14(9):3552-3564. PMC: 9562527. DOI: 10.21037/jtd-22-1122. View

14.

Faggioni R, Benigni F, Ghezzi P . Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections. Neuroimmunomodulation. 1995; 2(1):2-15. DOI: 10.1159/000096828. View

15.

Robinson R, Jorge R . Post-Stroke Depression: A Review. Am J Psychiatry. 2015; 173(3):221-31. DOI: 10.1176/appi.ajp.2015.15030363. View

16.

Guo J, Wang J, Sun W, Liu X . The advances of post-stroke depression: 2021 update. J Neurol. 2021; 269(3):1236-1249. DOI: 10.1007/s00415-021-10597-4. View

17.

Zimmerman M, Martinez J, Young D, Chelminski I, Dalrymple K . Severity classification on the Hamilton Depression Rating Scale. J Affect Disord. 2013; 150(2):384-8. DOI: 10.1016/j.jad.2013.04.028. View

18.

Ohlsson L, Gustafsson A, Lavant E, Suneson K, Brundin L, Westrin A . Leaky gut biomarkers in depression and suicidal behavior. Acta Psychiatr Scand. 2018; 139(2):185-193. PMC: 6587489. DOI: 10.1111/acps.12978. View

19.

Dimopoulou I, Tsagarakis S, Kouyialis A, Roussou P, Assithianakis G, Christoforaki M . Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels. Crit Care Med. 2004; 32(2):404-8. DOI: 10.1097/01.CCM.0000108885.37811.CA. View

20.

Turnbull A, Rivier C . Regulation of the HPA axis by cytokines. Brain Behav Immun. 1995; 9(4):253-75. DOI: 10.1006/brbi.1995.1026. View