Comparison of Weight Loss After Roux-en-Y Gastric Bypass in Helicobacter Pylori-negative and Helicobacter Pylori Eradicated Patients During Five Years Follow-ups

Overview

Journal Surg Endosc

Publisher Springer

Specialties Gastroenterology
General Surgery
Radiology

Date 2023 Dec 11

PMID 38082012

Authors

Behnood Farazmand

Masoumeh Shahsavan

Foolad Eghbali

Abdolreza Pazouki

Mohammad Kermansaravi

Affiliations

Soon will be listed here.

Abstract

Purpose: Helicobacter pylori (HP) is the most common human infection that has affected up to 50% of the population worldwide. The relationship between HP eradication and weight loss is under debate. The present study aimed to compare weight loss outcomes after Roux-en-Y gastric bypass (RYGB) in HP-negative (HP-) and HP-eradicated (HPe) patients during five years follow-ups.

Methods: This retrospective cohort study was conducted on 305 patients aged 18 and more with severe obesity, who underwent primary RYGB from February 2014 to November 2017. The HP-negative and HP-eradicated patients were evaluated for weight loss outcomes during five years follow-ups.

Results: Patients' mean age, mean weight, and mean body mass index were 38.78 ± 9.9, 114.8 ± 13.6, and 43.37 ± 2.55, respectively. 27.2% of patients who were HP-positive were treated before RYGB. There was no significant difference between the HP- and HPe patients in terms of total weight loss percent (%TWL), 12 to 60 months after RYGB. Excess weight loss percent (%EWL) was higher in HPe patients compared to HP- patients (P = 0.04) at 12-month after RYGB. However, there was no difference in %EWL between these two groups of patients, 36 and 60 months after RYGB.

Conclusion: The results of the present study showed that TWL% had no significant difference in HP- and HPe groups during five years follow-ups after RYGB. The %EWL was higher in HPe patients only at 12 months after RYGB and the difference did not persist over time.

References

Brown L . Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2001; 22(2):283-97. DOI: 10.1093/oxfordjournals.epirev.a018040. View

Mocanu V, Dang J, Switzer N, Skubleny D, Shi X, de Gara C . The Effect of Helicobacter pylori on Postoperative Outcomes in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. Obes Surg. 2017; 28(2):567-573. DOI: 10.1007/s11695-017-3024-8. View

Malfertheiner P, Megraud F, OMorain C, Atherton J, Axon A, Bazzoli F . Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut. 2012; 61(5):646-64. DOI: 10.1136/gutjnl-2012-302084. View

Patel S, Pratap C, Jain A, Gulati A, Nath G . Diagnosis of Helicobacter pylori: what should be the gold standard?. World J Gastroenterol. 2014; 20(36):12847-59. PMC: 4177467. DOI: 10.3748/wjg.v20.i36.12847. View

Wang Y, Kuo F, Liu C, Wu M, Shih H, Wang S . Diagnosis of Helicobacter pylori infection: Current options and developments. World J Gastroenterol. 2015; 21(40):11221-35. PMC: 4616200. DOI: 10.3748/wjg.v21.i40.11221. View

Testerman T, Morris J . Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. World J Gastroenterol. 2014; 20(36):12781-808. PMC: 4177463. DOI: 10.3748/wjg.v20.i36.12781. View

Chiappetta S, Stier C, Ghanem O, Abu Dayyeh B, Boskoski I, Prager G . Perioperative Interventions to Prevent Gastroesophageal Reflux Disease and Marginal Ulcers After Bariatric Surgery - an International Experts' Survey. Obes Surg. 2023; 33(5):1449-1462. DOI: 10.1007/s11695-023-06481-x. View

Kelly J, Perugini R, Wang Q, Czerniach D, Flahive J, Cohen P . The presence of Helicobacter pylori is not associated with long-term anastomotic complications in gastric bypass patients. Surg Endosc. 2015; 29(10):2885-90. DOI: 10.1007/s00464-014-4022-8. View

Zanotti D, Elkalaawy M, Hashemi M, Jenkinson A, Adamo M . Current Status of Preoperative Oesophago-Gastro-Duodenoscopy (OGD) in Bariatric NHS Units-a BOMSS Survey. Obes Surg. 2016; 26(9):2257-2262. DOI: 10.1007/s11695-016-2304-z. View

10.

Iwanczak F, Iwanczak B . Treatment of Helicobacter pylori infection in the aspect of increasing antibiotic resistance. Adv Clin Exp Med. 2013; 21(5):671-80. View

11.

Monno R, De Laurentiis V, Trerotoli P, Roselli A, Ierardi E, Portincasa P . Helicobacter pylori infection: association with dietary habits and socioeconomic conditions. Clin Res Hepatol Gastroenterol. 2019; 43(5):603-607. DOI: 10.1016/j.clinre.2018.10.002. View

12.

Hegde V, Dhurandhar N . Microbes and obesity--interrelationship between infection, adipose tissue and the immune system. Clin Microbiol Infect. 2013; 19(4):314-20. DOI: 10.1111/1469-0691.12157. View

13.

Erim T, Cruz-Correa M, Szomstein S, Velis E, Rosenthal R . Prevalence of Helicobacter pylori seropositivity among patients undergoing bariatric surgery: a preliminary study. World J Surg. 2008; 32(9):2021-5. DOI: 10.1007/s00268-008-9608-7. View

15.

Maksud F, Alves J, Diniz M, Barbosa A . Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients. Eur J Endocrinol. 2011; 165(1):57-62. DOI: 10.1530/EJE-11-0201. View

16.

Arslan E, Atilgan H, Yavasoglu I . The prevalence of Helicobacter pylori in obese subjects. Eur J Intern Med. 2009; 20(7):695-7. DOI: 10.1016/j.ejim.2009.07.013. View

17.

Xu M, Liu L, Yuan B, Yin J, Lu Q . Association of obesity with infection: A retrospective study. World J Gastroenterol. 2017; 23(15):2750-2756. PMC: 5403754. DOI: 10.3748/wjg.v23.i15.2750. View

18.

Kermansaravi M, Shahmiri S, Khalaj A, Jalali S, Amini M, Malekpour Alamdari N . The First Web-Based Iranian National Obesity and Metabolic Surgery Database (INOSD). Obes Surg. 2022; 32(6):2083-2086. DOI: 10.1007/s11695-022-06014-y. View

19.

Pazouki A, Kermansaravi M . Single Anastomosis Sleeve-Jejunal Bypass: a New Method of Bariatric/Metabolic Surgery. Obes Surg. 2019; 29(11):3769-3770. DOI: 10.1007/s11695-019-04016-x. View

20.

Kermansaravi M, Parmar C, Chiappetta S, Shikora S, Aminian A, Abbas S . Best practice approach for redo-surgeries after sleeve gastrectomy, an expert's modified Delphi consensus. Surg Endosc. 2023; 37(3):1617-1628. DOI: 10.1007/s00464-023-09879-x. View

21.

Hooi J, Lai W, Ng W, Suen M, Underwood F, Tanyingoh D . Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017; 153(2):420-429. DOI: 10.1053/j.gastro.2017.04.022. View